Intradialytic hypertension (iHTN) has been related with an increased risk of mortality, with imbalances in trace elements being frequent in maintenance hemodialysis (MHD) patients. The aim of this study was to analyze the relationships between the levels of blood trace elements and iHTN in MHD patients. A total of 144 MHD patients were enrolled in September, 2019 (66 females; 5616 hemodialysis treatments), with a mean age of 64.33 ± 13.39 years and median vintage of 33.50 (16.25–57.50) months. Patients exhibited an average peridialytic systolic blood pressure (SBP) change of − 4.18 ± 20.22 mm Hg in the next 3 months. Thirty-four (23.6%) patients had persistent iHTN (piHTN). These patients were characterized by older age, higher rate of hypozincemia, and modified Charlson comorbidity score, whereas lower blood zinc and hemoglobin, at the time of their recruitment. No significant difference in the levels of other blood trace elements was observed between groups. A general linear mixed (GLM) model showed that with every mg/L point lower mean blood zinc at baseline, the peridialytic SBP change was increased by 4.524 mm Hg (P < 0.001). Binary logistic model in modulate of the GLM model revealed that the lower level of blood zinc was associated with piHTN (OR = 0.433, 95 % CI 0.295 to 0.637, P < 0.001). Multivariate analysis confirmed both above results. Our study indicated that lower blood zinc was independently associated with piHTN in patients undergoing MHD, but prospective studies with larger population are still needed.

透析中高血压 (iHTN) 与死亡风险增加有关，维持性血液透析 (MHD) 患者的微量元素失衡很常见。本研究旨在分析MHD患者血液微量元素水平与iHTN之间的关系。2019 年 9 月共招募了 144 名 MHD 患者（66 名女性；5616 次血液透析治疗），平均年龄为 64.33 ± 13.39 岁，中位年龄为 33.50（16.25-57.50）个月。在接下来的 3 个月内，患者的平均透析周收缩压 (SBP) 变化为 - 4.18 ± 20.22 mmHg。34 名 (23.6%) 患者患有持续性 iHTN (piHTN)。这些患者的特点是年龄较大、低锌血症发生率较高、Charlson 合并症评分较高，而血锌和血红蛋白较低，在他们招聘时。组间未观察到其他血液微量元素水平的显着差异。一般线性混合 (GLM) 模型显示，基线时平均血锌每降低一个 mg/L 点，透析周 SBP 变化就会增加 4.524 mm Hg。P < 0.001)。调节 GLM 模型的二元逻辑模型显示较低的血锌水平与 piHTN 相关（OR = 0.433，95% CI 0.295 至 0.637，P < 0.001）。多变量分析证实了上述两个结果。我们的研究表明，在接受 MHD 的患者中，较低的血锌与 piHTN 独立相关，但仍需要更大人群的前瞻性研究。