With the continuing advancement of carbohydrate chemical synthesis, bacterial glycomes have become increasingly attractive and accessible synthetic targets. Although bacteria also produce carbohydrate-containing secondary metabolites, our review here will cover recent chemical synthetic efforts on bacterial surface glycans. The obtained compounds are excellent candidates for the development of improved structurally defined glycoconjugate vaccines to combat bacterial infections. They are also important probes for investigating glycan-protein interactions. Glycosylation strategies applied for the formation of some challenging glycosidic bonds of various uncommon sugars in a number of recently synthesized bacterial surface glycans are highlighted.

中文翻译：

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细菌表面聚糖的化学合成新进展。

随着碳水化合物化学合成的不断进步，细菌糖组已成为越来越有吸引力和可及的合成目标。尽管细菌也会产生含碳水化合物的次级代谢产物，但我们在此的综述将涵盖最近对细菌表面聚糖进行的化学合成工作。获得的化合物是开发改进结构定义的糖缀合物疫苗以对抗细菌感染的极好候选者。它们也是研究聚糖-蛋白质相互作用的重要探针。重点介绍了用于在许多最近合成的细菌表面聚糖中形成各种不常见糖的一些具有挑战性的糖苷键的糖基化策略。