The authors aimed to compare the effects of creatine (Cr) supplementation combined with resistance training on skeletal muscle mass (SMM), total body water, intracellular water (ICW), and extracellular water (ECW) in resistance-trained men as well as to determine whether the SMM/ICW ratio changes in response to the use of this ergogenic aid. Twenty-seven resistance-trained men received either Cr (n = 14) or placebo (n = 13) over 8 weeks. During the same period, subjects performed two split resistance training routines four times per week. SMM was estimated from appendicular lean soft tissue assessed by dual-energy X-ray absorptiometry. Total body water, ICW, and ECW were determined by spectral bioelectrical impedance. Both groups showed improvements (p < .05) in SMM, total body water, and ICW, with greater values observed for the Cr group compared with placebo. ECW increased similarly in both groups (p < .05). The SMM/ICW ratio did not change in either group (p > .05), whereas the SMM/ECW ratio decreased only in the Cr group (p < .05). A positive correlation was observed (p < .05) between SMM and ICW changes (r = .71). The authors’ results suggest that the increase in muscle mass induced by Cr combined with resistance training occurs without alteration of the ratio of ICW to SMM in resistance-trained men.

作者旨在比较肌酸 (Cr) 补充结合阻力训练对接受阻力训练的男性骨骼肌质量 (SMM)、全身水分、细胞内水分 (ICW) 和细胞外水分 (ECW) 的影响，以及确定 SMM/ICW 比率是否因使用这种增效剂而发生变化。27 名接受过阻力训练的男性 在 8 周内接受了 Cr ( n  = 14) 或安慰剂 ( n = 13)。在同一时期，受试者每周进行四次两次分次阻力训练。SMM 是通过双能 X 射线吸收测定法评估的阑尾瘦软组织来估计的。通过光谱生物电阻抗测定体内总水分、ICW 和 ECW。两组的 SMM、全身水分和 ICW均有所改善 ( p < .05)，与安慰剂相比，Cr 组观察到的值更高。两组 ECW 增加相似 ( p  < .05)。两组中的 SMM/ICW 比率均未发生变化 ( p  > .05)，而 SMM/ECW 比率仅在 Cr 组中下降 ( p  < .05)。 SMM 和 ICW 变化 ( r = .71) 之间观察到正相关 ( p < .05)  。作者的结果表明，在进行阻力训练的男性中，Cr 与阻力训练相结合诱导的肌肉质量增加不会改变 ICW 与 SMM 的比率。