Boric acid and omega-3 are used as essential elements for both animal and human health. Many researchers have shown these beneficial effects on cardiac and inflammatory markers. This study aims to evaluate cardiac protective effect of boric acid and omega-3 against MI (myocardial infarction), probably due to the suppression of pro-inflammatory cytokines of natriuretic peptides in rats. Fifty male Sprague-Dawley rats were randomly divided into five groups: control, MI, MI+boric acid, MI+omega-3, and MI+boric acid+omega-3. Saline solution (2 ml/day), omega-3 (800 mg/kg/day), and boric acid (100 mg/kg/day)+omega-3 (800 mg/kg/day) were orally administered to the relevant groups throughout the 28 days. To constitute the MI model, the rats were exposed to isoproterenol-HCl (ISO) (200 mg/kg, S.C.) on the 27th and 28th. In the MI group, serum levels of CK-MB, BNP, and TNF-α are increased significantly. Also, ST waves and heart rates were higher in the MI than the control. These results demonstrate that biochemical results healed in MI+boric acid, MI+omega-3, and MI+boric acid+omega-3 groups compared MI group. ECG and light microscope results supported the findings as well. The statistical analysis showed that boric acid and/or omega-3 has protective effects on cellular damage in MI.

中文翻译：

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硼酸和 Omega-3 对实验大鼠模型心肌梗塞的保护作用。

硼酸和 omega-3 被用作动物和人类健康的必需元素。许多研究人员已经证明了这些对心脏和炎症标志物的有益影响。本研究旨在评估硼酸和 omega-3 对 MI（心肌梗塞）的心脏保护作用，这可能是由于抑制了大鼠利钠肽的促炎细胞因子。50只雄性Sprague-Dawley大鼠随机分为5组：对照组、MI、MI+硼酸、MI+omega-3和MI+硼酸+omega-3。将生理盐水（2 毫升/天）、omega-3（800 毫克/公斤/天）和硼酸（100 毫克/公斤/天）+omega-3（800 毫克/公斤/天）口服给相关的整个 28 天的小组。为了构建 MI 模型，大鼠在 27 日和 28 日暴露于异丙肾上腺素-HCl (ISO) (200 mg/kg, SC)。在MI组中，CK-MB、BNP 和 TNF-α 的血清水平显着升高。此外，MI 组的 ST 波和心率高于对照组。这些结果表明，MI+硼酸组、MI+omega-3组和MI+硼酸+omega-3组生化结果愈合，与MI组相比。心电图和光学显微镜结果也支持了这些发现。统计分析表明，硼酸和/或 omega-3 对 MI 中的细胞损伤具有保护作用。