The COVID-19 pandemic continues to wreak havoc worldwide due to the lack of risk assessment, rapid spreading ability, and propensity to precipitate severe disease in comorbid conditions. In an attempt to fulfill the demand for prophylactic and treatment measures to intercept the ongoing outbreak, the drug development process is facing several obstacles and renaissance in clinical trials, including vaccines, antivirals, immunomodulators, plasma therapy, and traditional medicines. This review outlines the overview of SARS-CoV-2 infection, significant recent findings, and ongoing clinical trials concerning current and future therapeutic interventions for the management of advancing pandemic of the century.

由于缺乏风险评估，快速的传播能力以及在合并症中诱发严重疾病的倾向，COVID-19大流行继续在全球范围内造成严重破坏。为了满足对预防和治疗措施的需求以拦截持续的爆发，药物开发过程在临床试验中面临着许多障碍和复兴，包括疫苗，抗病毒药，免疫调节剂，血浆疗法和传统药物。这篇综述概述了SARS-CoV-2感染的概述，重要的近期发现以及与当前和未来世纪治疗大流行流行的治疗措施有关的临床试验。