The mammalian immune system can tune its inflammatory response to the threat level posed by an invading pathogen. It is well established that the host utilizes numerous 'patterns of pathogenicity', such as microbial growth, invasion, and viability, to achieve this tuning during bacterial infections. This review discusses how this notion fits during fungal infection, particularly regarding Aspergillus fumigatus infection. Moreover, how the environmental niches filled by A. fumigatus may drive the evolution of the fungal traits responsible for inducing the strain-specific inflammatory responses that have been experimentally observed will be discussed. Moving forward understanding the mechanisms of the fungal strain-specific inflammatory response due to the initial interactions with the host innate immune system will be essential for enhancing our therapeutic options for the treatment of invasive fungal infections.

中文翻译：

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感知曲霉感染带来的威胁。

哺乳动物免疫系统可以根据入侵病原体构成的威胁水平调整其炎症反应。众所周知，宿主利用多种“致病模式”，例如微生物生长、入侵和生存能力，在细菌感染期间实现这种调整。这篇综述讨论了这个概念在真菌感染期间如何适用，特别是关于烟曲霉感染。此外，还将讨论由烟曲霉填充的环境生态位如何推动真菌性状的进化，这些性状负责诱导实验观察到的菌株特异性炎症反应。