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"Reports of My Death Were Greatly Exaggerated": Behavior Genetics in the Postgenomic Era.
Annual Review of Psychology ( IF 23.6 ) Pub Date : 2021-01-05 , DOI: 10.1146/annurev-psych-052220-103822
K Paige Harden 1
Affiliation  

Behavior genetics studies how genetic differences among people contribute to differences in their psychology and behavior. Here, I describe how the conclusions and methods of behavior genetics have evolved in the postgenomic era in which the human genome can be directly measured. First, I revisit the first law of behavioral genetics stating that everything is heritable, and I describe results from large-scale meta-analyses of twin data and new methods for estimating heritability using measured DNA. Second, I describe new methods in statistical genetics, including genome-wide association studies and polygenic score analyses. Third, I describe the next generation of work on gene × environment interaction, with a particular focus on how genetic influences vary across sociopolitical contexts and exogenous environments. Genomic technology has ushered in a golden age of new tools to address enduring questions about how genes and environments combine to create unique human lives.

中文翻译:


“关于我的死亡的报道被极大地夸大了”:后基因组时代的行为遗传学。

行为遗传学研究人们之间的遗传差异如何影响他们的心理和行为差异。在这里,我描述了在可以直接测量人类基因组的后基因组时代,行为遗传学的结论和方法是如何演变的。首先,我回顾了行为遗传学的第一定律,即一切都是可遗传的,并且描述了对双胞胎数据进行大规模荟萃分析的结果以及使用测量的 DNA 估计遗传力的新方法。其次,我描述了统计遗传学的新方法,包括全基因组关联研究和多基因评分分析。第三,我描述了关于基因×环境相互作用的下一代工作,特别关注遗传影响如何在社会政治背景和外源环境中变化。基因组技术开创了新工具的黄金时代,以解决有关基因和环境如何结合创造独特人类生活的持久问题。

更新日期:2021-01-06
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