Regulation of hypnosis level on bi-spectral index monitor (BIS) during a surgical procedure in propofol anaesthesia administration is a challenging task for an anaesthesiologist in multi-tasking environment of the operation theater. Automation in anaesthesia has the potential to solve issues arising from manual administration. Automation in anaesthesia is based on developing the three-compartmental model including pharmacokinetics and pharmacodynamic of the silico patients. This study focuses on regulation of the hypnosis level in the presence of surgical stimulus including skin incision, surgical diathermy and laryngoscopy as well as inter-patient variability by designing super-twisting sliding mode control (STSMC). The depth of the hypnosis level is maintained to 50 on the BIS level in the maintenance phase after improving the induction phase to 60 s using the conventional sliding mode control and 30 s with STSMC. The proposed scheme also compensates the inter-patient variability dynamics including height, age and weight of the different silico patients. Moreover, the surgical stimuli direct the hypnosis level towards the state of consciousness and stimulate the controller to provide continuous drug infusion during the interval 80-90 s. Simulation results witness that the oscillatory behaviour is observed in drug infusion to ensure the moderate level of hypnosis (40-60) for general surgery.

中文翻译：

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异丙酚麻醉中的催眠调节采用超扭转滑模控制来补偿动态变化。


在异丙酚麻醉的外科手术过程中调节双频指数监测仪（BIS）的催眠水平对于手术室多任务环境中的麻醉师来说是一项具有挑战性的任务。麻醉自动化有可能解决手动管理引起的问题。麻醉自动化基于开发三室模型，包括计算机患者的药代动力学和药效学。本研究的重点是通过设计超扭转滑动模式控制（STSMC）来调节手术刺激（包括皮肤切口、手术透热疗法和喉镜检查）下的催眠水平以及患者间的变异性。使用传统滑模控制将诱导阶段提高到 60 秒，使用 STSMC 将诱导阶段提高到 30 秒后，维持阶段的 BIS 水平催眠深度保持在 50。所提出的方案还补偿了患者间的动态变化，包括不同计算机患者的身高、年龄和体重。此外，手术刺激将催眠水平引导至意识状态，并刺激控制器在80-90秒的时间间隔内提供连续的药物输注。模拟结果表明，在药物输注中观察到振荡行为，以确保普通手术的中等催眠水平（40-60）。