BACKGROUND: Postoperative pain is an important factor affecting anesthesia and surgery.OBBJECTIVES: The present study assessed the effects of 1200 mg gabapentin, an anticonvulsant drug that acts through voltage-dependent calcium channels, for the control of postoperative pain in patients undergoing abdominal hysterectomy.METHODS: Fifty patients undergoing hysterectomy were enrolled in the present study. Subjects received either 1200 mg gabapentin or placebo 2 h before surgery. The amount of morphine consumption and level of postoperative pain at 2 h, 6 h, 12 h and 24 h after surgery were measured.RESULTS: There were no significant differences in age, duration of surgery and anesthesia, or body mass index between the two groups. The mean intensity of pain in the gabapentin group was significantly lower than in the placebo group. The mean amount of morphine used in the placebo group (5.2±2.8 mg) was significantly higher than in gabapentin group (1.2±0.29 mg; P=0.001). Nausea and vomiting in the placebo group was more common than in the gabapentin group (P=0.001). The time interval for initial ambulation after surgery was significantly shorter in the gabapentin group (12.24±2.18 h) compared with the placebo group (15±3.61 h; P=0.002).CONCLUSION: 1200 mg gabapentin reduced postoperative pain and the need for opioids, and enabled earlier ambulation of the patient. Significant side effects were not observed.

中文翻译：

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加巴喷丁对腹部子宫切除术后疼痛和阿片类药物消耗的影响

背景：术后疼痛是影响麻醉和手术的重要因素。目的：本研究评估了1200 mg加巴喷丁（一种通过电压依赖性钙通道起作用的抗惊厥药）对腹部子宫切除术患者术后疼痛的控制作用。方法：本研究纳入了50例行子宫切除术的患者。受试者在手术前2小时接受1200 mg加巴喷丁或安慰剂。测量术后2 h，6 h，12 h和24 h的吗啡消耗量和术后疼痛程度。结果：两者的年龄，手术时间和麻醉时间或体重指数之间无显着差异组。加巴喷丁组的平均疼痛强度明显低于安慰剂组。安慰剂组的平均吗啡用量（5.2±2.8 mg）显着高于加巴喷丁组（1.2±0.29 mg； P = 0.001）。安慰剂组的恶心和呕吐比加巴喷丁组更常见（P = 0.001）。加巴喷丁组（12.24±2.18 h）的术后初次活动时间比安慰剂组（15±3.61 h； P = 0.002）明显缩短。结论：1200 mg加巴喷丁可减轻术后疼痛和对阿片类药物的需求，并使患者能够更早地移动。没有观察到明显的副作用。加巴喷丁组（12.24±2.18 h）的术后初次活动时间比安慰剂组（15±3.61 h； P = 0.002）明显缩短。结论：1200 mg加巴喷丁可减轻术后疼痛和对阿片类药物的需求，并使患者能够更早地移动。没有观察到明显的副作用。加巴喷丁组（12.24±2.18 h）的术后初次活动时间比安慰剂组（15±3.61 h； P = 0.002）明显缩短。结论：1200 mg加巴喷丁可减轻术后疼痛和对阿片类药物的需求，并使患者能够更早地移动。没有观察到明显的副作用。