New amidine and benzene sulfonamide derivatives were developed and structures of the new products were confirmed by elemental and spectral analysis (FT-IR, ESI-MS, 1HNMR, and 13CNMR). In vitro, developed compounds were screened for their antibacterial and antifungal activities against medically important bacterial strains, namely, S. aureus, B. subtilis, and E. coli, and fungi, namely, A. flavus, A. parasiticus, and A. sp. The antibacterial and antifungal activities have been determined by measuring MIC values (μg/mL) and zone of inhibitions (mm). Among the tested compounds, it was found that compounds 3b, 9a, and 9b have most potent activity against S. aureus, A. flavus, and A. parasiticus, respectively, and were found to be more active than sulfamethoxazole and itraconazole with MIC values 40 μg/mL. In contrast, all the compounds were totally inactive against the A. sp. except 10b and 15b to show activity to some extent.

中文翻译：

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脒磺酰胺和苯磺酰胺：合成及其生物学评价

开发了新的脒和苯磺酰胺衍生物，并通过元素和光谱分析（FT-IR、ESI-MS、1HNMR 和 13CNMR）确认了新产品的结构。在体外，筛选开发的化合物对医学上重要的细菌菌株（即金黄色葡萄球菌、枯草芽孢杆菌和大肠杆菌）和真菌（即 A. flavus、A. parasiticus 和 A. sp. 抗菌和抗真菌活性已通过测量 MIC 值 (μg/mL) 和抑菌圈 (mm) 确定。在测试的化合物中，发现化合物 3b、9a 和 9b 分别对金黄色葡萄球菌、黄曲霉和寄生曲霉具有最强的活性，并且在 MIC 值下比磺胺甲恶唑和伊曲康唑的活性更强40 微克/毫升。相比之下，所有化合物对 A. sp 完全无活性。除了 10b 和 15b 显示出一定程度的活性。