当前位置：
X-MOL 学术
›
Parkinson's Dis.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Validation of Revised Chinese Version of PD-CRS in Parkinson’s Disease Patients
Parkinson's Disease ( IF 2.1 ) Pub Date : 2020-02-19 , DOI: 10.1155/2020/5289136 Yuyan Tan 1 , Weiguo Liu 2 , Juanjuan Du 3 , Miaomiao Hou 1 , Cuiyu Yu 2 , Yang Liu 4 , Shishuang Cui 1 , Lei Yan 2 , Yizhou Lu 1 , Hong Lv 4 , Lijun Han 2 , Xi Wang 1 , Shengyu Zha 1 , Xiaoguang Luo 5 , Huidong Tang 1 , Shengdi Chen 1
Parkinson's Disease ( IF 2.1 ) Pub Date : 2020-02-19 , DOI: 10.1155/2020/5289136 Yuyan Tan 1 , Weiguo Liu 2 , Juanjuan Du 3 , Miaomiao Hou 1 , Cuiyu Yu 2 , Yang Liu 4 , Shishuang Cui 1 , Lei Yan 2 , Yizhou Lu 1 , Hong Lv 4 , Lijun Han 2 , Xi Wang 1 , Shengyu Zha 1 , Xiaoguang Luo 5 , Huidong Tang 1 , Shengdi Chen 1
Affiliation
There is a high prevalence of mild cognitive impairment (MCI) and dementia in Parkinson’s disease (PD) patients, but a Chinese version of cognitive rating scale that is specific and sensitive to PD patients is still lacking. The aims of this study are to test the reliability and validity of a Chinese version of Parkinson’s disease-cognitive rating scale (PD-CRS), establish cutoff scores for diagnosis of Parkinson’s disease dementia (PDD) and PD with mild cognitive impairment (PD-MCI), explore cognitive profiles of PD-MCI and PDD, and find cognitive deficits suggesting a transition from PD-MCI to PDD. PD-CRS was revised based on the culture background of Chinese people. Ninety-two PD patients were recruited in three PD centers and were classified into PD with normal cognitive function (PD-NC), PD-MCI, and PDD subgroups according to the cognitive rating scale (CDR). Those PD patients underwent PD-CRS blind assessment by a separate neurologist. The PD-CRS showed a high internal consistency (Cronbach’s Alpha = 0.840). Intraclass Correlation coefficient (ICC) of test-retest reliability reached 0.906 (95% CI 0.860–0.935, ). ICC of inter-rater reliability was 0.899 (95% CI 0.848–0.933, ). PD-CRS had fair concurrent validity with MDRS (ICC = 0.731, 95% CI 0.602–0.816). All the frontal-subcortical items showed significant decrease in PD-MCI compared with the PD-NC group (), but the instrument cortical items did not (confrontation naming , copying a clock ). All the frontal-subcortical and instrumental-cortical functions showed significant decline in PDD compared with the PD-NC group (). The cutoff value for diagnosis of PD-MCI is 80.5 with the sensitivity of 75.7% and the specificity of 75.0%, and for diagnosis of PDD is 73.5 with the sensitivity of 89.2% and the specificity of 98.9%. Revised Chinese version of PD-CRS is a reliable, acceptable, valid, and useful neuropsychological battery for assessing cognition in PD patients.
更新日期：2020-02-19
京公网安备 11010802027423号