Introduction. Parkinson’s disease (PD) is the second most common neurodegenerative disease after Alzheimer’s disease (AD). With the ageing of population, the frequency of PD is expected to increase dramatically in the coming decades. L-DOPA (1,3,4-dihydroxyalanine) is the most effective drug in the symptomatic treatment of PD. Nonmotor symptoms in PD include sleep problems, depression, and dementia, which are not adequately controlled with dopaminergic therapy. Here, we report the efficacy of oral administration of scallop-derived ether phospholipids to some nonmotor symptoms of PD. Methods. Ten (10) patients received oral administration of 1 mg/day of purified ether phospholipids derived from scallop for 24 weeks. Clinical symptoms and blood tests were checked at 0, 4, 12, 24, and 28 weeks. The blood levels of plasmalogens in patients with PD were compared with those of 39 age-matched normal controls. Results. Initial levels of plasma ethanolamine ether phospholipids in PD and ethanolamine plasmalogen of erythrocyte from PD were lower than those of age-matched normal controls. Oral administration of 1 mg/day of the purified ether phospholipids increased plasma ether phospholipids in PD and increased the relative composition of ether phospholipids of erythrocyte membrane in PD. The levels of ether phospholipids in peripheral blood reached to almost normal levels after 24 weeks. Furthermore, some clinical symptoms of PD improved concomitantly. Conclusion. 1 mg/day of oral administration of purified ether phospholipids derived from scallop can increase ether phospholipids in peripheral blood and concomitantly improve some clinical symptoms of PD.

中文翻译：

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口服醚磷脂对帕金森病的血浆缩醛磷脂和临床症状的改善：初步报告

简介。帕金森病 (PD) 是仅次于阿尔茨海默病 (AD) 的第二常见的神经退行性疾病。随着人口老龄化，预计未来几十年PD的频率将急剧增加。L-DOPA（1,3,4-二羟基丙氨酸）是PD对症治疗中最有效的药物。PD 的非运动症状包括睡眠问题、抑郁和痴呆，而多巴胺能治疗无法充分控制这些症状。在这里，我们报告了口服扇贝衍生的醚磷脂对一些 PD 非运动症状的疗效。方法. 十 (10) 名患者接受 1 mg/天的从扇贝中提取的纯化醚磷脂口服给药 24 周。在第 0、4、12、24 和 28 周检查临床症状和血液检查。将 PD 患者的缩醛磷脂水平与 39 名年龄匹配的正常对照进行比较。结果. PD中血浆乙醇胺醚磷脂和PD红细胞乙醇胺缩醛磷脂的初始水平低于年龄匹配的正常对照。口服1mg/天的纯化醚磷脂增加了PD中血浆醚磷脂，增加了PD中红细胞膜醚磷脂的相对组成。24周后外周血中的醚磷脂水平几乎达到正常水平。此外，PD的一些临床症状也随之改善。结论。扇贝纯化醚磷脂1mg/天口服给药，可增加外周血醚磷脂，同时改善部分PD临床症状。