The objective of this study was to evaluate the effects of a three-strain yogurt formulation in slow-transit constipation (STC) patients. Each individual in both treatment groups consumed 250 mL of the formulated yogurt daily for a week (7 days), and fecal samples were collected for gut microbiota and short-chain fatty acid (SCFA) analyses. A significant increase in the defection frequency () and bacterial diversity () at the 100% sequence homology level and a decrease in the concentrations of acetic acid (), propionic acid (), and butanoic acid () were observed after the STC patients consumed three-strain yogurt formulation. In addition, the consumption of the three-strain yogurt formulation significantly altered the composition of the intestinal bacteria in the STC patients. The relative abundances of 23 genera in the top dominating genera were altered significantly after the STC patients consumed the yogurt. In summary, the consumption of 250 mL day⁻ the three-strain yogurt formulation described in this study can play a role in improving the symptoms of STC.

中文翻译：

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慢速便秘中三菌种酸奶配方治疗的肠道菌群改变

这项研究的目的是评估慢应变便秘（STC）患者中的三株酸奶配方的效果。两个治疗组中的每个人每天（一周）（7天）每天食用250 mL配制的酸奶，并收集粪便样品进行肠道菌群和短链脂肪酸（SCFA）分析。在100％的序列同源性水平上，缺陷发生频率（）和细菌多样性（）显着增加，而乙酸（），丙酸（）和丁酸（）的浓度降低在STC患者食用三株酸奶配方后进行观察。另外，三菌株酸奶制剂的消耗显着改变了STC患者中肠细菌的组成。在STC患者喝酸奶后，最主要的23个属的相对丰度发生了显着变化。总之，250毫升一天的消耗^-在本研究中描述的三应变酸奶制剂可以在提高STC的症状中起作用。