Parkinson’s disease (PD) is a chronic progressive movement disorder with severe reduction in patients’ health-related quality of life (HR-QoL). Motor and cognitive symptoms are especially linked with decreased PD patients’ HR-QoL. However, the relationship of these symptoms to caregiver burden is relatively unclear. Influence of the Montreal Cognitive Assessment scale (MoCA) as a cognitive screening tool and Movement Disorders Society Unified Parkinson’s disease Rating Scale MDS-UPDRS symptoms in relation to patients’ HR-QoL and caregivers` burden was analyzed. PD patients (n = 124) completed MDS-UPDRS, MoCA, and the PD questionnaire 8 (PDQ-8) as a measure of quality of life. Caregivers (n = 78) were assessed by the PD caregiver burden inventory (PDCB). PDQ-8 and PDCB scores were regressed on MDS-UPDRS subscales and MoCA subscores. PDQ-8 correlated with attention (R² 0.1282; ) and executive (R² 0.0882; 0.001) MoCA subscores and all parts of the MDS-UPDRS. PDCB correlated most strongly with MDS-UPDRS part III motor symptoms (R² 0.2070; ) and the MoCA attention subscore (R² 0.1815; ). While all facets of PD symptoms assessed by the MDS-UPDRS relate to PD patients’ quality of life, motor symptoms are the most relevant factor for the prediction of caregiver burden. In addition, patients’ attentional symptoms seem to affect not only them, but also their caregivers. These findings show the potential of a detailed analysis of MDS-UPDRS and MoCA performance in PD patients.

中文翻译：

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运动和认知症状与德国帕金森氏病晚期患者队列中与健康相关的生活质量和护理人员负担的关联

帕金森氏病（PD）是一种慢性进行性运动障碍，会严重降低患者与健康相关的生活质量（HR-QoL）。运动和认知症状尤其与PD患者的HR-QoL降低有关。但是，这些症状与护理人员负担之间的关系还不清楚。分析了作为认知筛查工具的蒙特利尔认知评估量表（MoCA）和运动障碍协会统一帕金森氏疾病评分量表MDS-UPDRS症状与患者HR-QoL和看护者负担的关系。PD患者（n  = 124）完成了MDS-UPDRS，MoCA和PD调查表8（PDQ-8），以衡量生活质量。照顾者（ñ = 78）由PD照料者负担清单（PDCB）进行了评估。PDQ-8和PDCB分数在MDS-UPDRS子量表和MoCA子量表上进行回归。PDQ-8与注意力（R ² 0.1282; ）和执行者（R ² 0.0882; 0.001）与MoCA评分以及MDS-UPDRS的所有部分相关。PDCB与MDS-UPDRS第三部分运动症状（R ² 0.2070; ）和MoCA注意分（R ² 0.1815; ）密切相关。通过MDS-UPDRS评估的PD症状的所有方面都与PD患者的生活质量有关，而运动症状是预测护理人员负担的最相关因素。另外，患者的注意症状似乎不仅影响他们，而且影响他们的照料者。这些发现显示了对PD患者中MDS-UPDRS和MoCA表现进行详细分析的潜力。