The hydantoin moiety is found in several bioactive compounds with important pharmacological properties such as antimicrobial, antifungal, anti-androgens, anticancer and the historical action anticonvulsant. Because of these reasons, the synthesis of these compounds and their derivatives is important to review considering the philosophy of the green chemistry. In this review, we present the actual importance in the green synthesis of hydantoins and their derivatives using green methods, such as microwave and ultrasound irradiation, ionic liquids, solid-phase and solvent-free synthesis. Finally, several green protocols reported have been discussed.

中文翻译：

---

乙内酰脲及其衍生物的绿色合成

乙内酰脲部分存在于几种具有重要药理特性的生物活性化合物中，例如抗微生物剂，抗真菌剂，抗雄激素，抗癌药和具有抗惊厥作用的历史药。由于这些原因，考虑到绿色化学的原理，对这些化合物及其衍生物的合成进行审查非常重要。在这篇综述中，我们介绍了使用绿色方法绿色合成乙内酰脲及其衍生物的实际重要性，例如微波和超声辐射，离子液体，固相和无溶剂合成。最后，已经讨论了几种绿色协议。