Background: Near to 5-7 million people are infected with T. cruzi in the world, and about 10,000 people per year die of problems associated with this disease.

Methods: Herein, the synthesis, antitrypanosomal and antimycobacterial activities of seventeen coumarinic N-acylhydrazonic derivatives have been reported.

Results: These compounds were synthesized using methodology with reactions global yields ranging from 46%-70%. T. cruzi in vitro effects were evaluated against trypomastigote and amastigote, forming M. tuberculosis activity towards H37Rv sensitive strain and resistant strains.

Discussion: Against T. cruzi, the more active compounds revealed only moderate activity IC₅₀/96h~20 μM for both trypomastigotes and amastigotes intracellular forms. (E)-2-oxo-N'- (3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide showed meaningful activity in INH resistant/RIP resistant strain.

Conclusion: These compound acting as multitarget could be good leads for the development of new trypanocidal and bactericidal agents.

背景：世界上有近 5-7 百万人感染了克氏锥虫，每年约有 10,000 人死于与这种疾病相关的问题。

方法：本文报道了十七种香豆素 N-酰基肼衍生物的合成、抗锥虫和抗分枝杆菌活性。

结果：这些化合物是使用方法合成的，反应全球产率范围为 46%-70%。针对锥鞭毛体和无鞭毛体评估了 T. cruzi 体外效果，形成了对 H37Rv 敏感菌株和抗性菌株的结核分枝杆菌活性。

讨论：针对 T. cruzi，活性更强的化合物对锥鞭毛体和无鞭毛体细胞内形式仅显示中等活性 IC ₅₀ /96h~20 μM。(E)-2-oxo-N'-(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide 在 INH 抗性/RIP 抗性菌株中显示出有意义的活性。

结论：这些作为多靶点的化合物可能是开发新型杀锥虫剂和杀菌剂的良好先导。