Background: Increasing the bioactivity of metallic implants is necessary for biomaterial applications where hydroxyapatite (HA) is used as a surface coating. In industry, HA is currently coated by plasma spraying, but this technique has a high cost and produces coating with short-term stability.

Objectives: In the present study, electrophoretic deposition (EPD) was used to deposit nano-biphasic calcium phosphate compound (β-tri-calcium phosphate (β-TCP) /hydroxyapatite (HA)) bio-ceramics on the titanium surface. The microstructural, chemical compositions and bioactivity of the β- TCP/HA coatings were studied in a simulated body fluid solution (SBF).

Methods: Scanning electron microscopy (SEM) equipped with energy-dispersive X-ray spectroscopy (EDX) and Fourier transform infrared spectroscopy (FTIR) were used. Additionally, the antibacterial effect was studied by the agar diffusion method. The corrosion behavior of the β-TCP/HA coating on titanium surface (Ti) in the SBF solution at 37oC was investigated by means of electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization tests.

Results: The Ti surface modification increased its biocompatibility and corrosion resistance in the simulated body fluid. The antibacterial inhibition activity of the β-TCP/HA bio-ceramic was enhanced by electroless silver deposition. The enhanced properties could be attributed to the use of nano-sized biphasic calcium phosphates in a low-temperature EPD process.

Conclusion: The β-TCP/HA and β-TCP/HA/Ag coatings well protect Ti from the corrosion in SBF and endow Ti with biocompatibility. The β-4-TCP/HA/Ag/Ti substrate shows good antibacterial activity.

背景：对于将羟基磷灰石（HA）用作表面涂层的生物材料应用，必须提高金属植入物的生物活性。在工业上，HA目前通过等离子喷涂进行涂覆，但是该技术成本高昂，并且具有短期稳定性。

目的：在本研究中，电泳沉积（EPD）用于在钛表面沉积纳米双相磷酸钙化合物（β-磷酸三钙（β-TCP）/羟基磷灰石（HA））生物陶瓷。在模拟体液溶液（SBF）中研究了β-TCP/ HA涂层的微观结构，化学成分和生物活性。

方法：使用配有能量色散X射线光谱仪（EDX）和傅里叶变换红外光谱仪（FTIR）的扫描电子显微镜（SEM）。另外，通过琼脂扩散法研究了抗菌效果。通过电化学阻抗谱（EIS）和电势极化试验研究了37°C下SBF溶液中钛表面（Ti）上β-TCP/ HA涂层的腐蚀行为。

结果：Ti表面改性提高了其在模拟体液中的生物相容性和耐腐蚀性。化学镀银可增强β-TCP/ HA生物陶瓷的抑菌活性。增强的性能可归因于在低温EPD工艺中使用纳米级双相磷酸钙。

结论：β-TCP/ HA和β-TCP/ HA / Ag涂层能很好地保护Ti免受SBF的腐蚀，并赋予Ti具有生物相容性。β-4-TCP/ HA / Ag / Ti底物显示出良好的抗菌活性。