A Review on the Synthesis and Biological Studies of 2,4-Thiazolidinedione Derivatives,Mini-Reviews in Organic Chemistry

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A Review on the Synthesis and Biological Studies of 2,4-Thiazolidinedione Derivatives
Mini-Reviews in Organic Chemistry ( IF 1.9 ) Pub Date : 2020-11-30 , DOI: 10.2174/1570193x17666200221123633
Srinivasa Reddy Bireddy ₁ , Veera Swamy Konkala ₂ , Chandraiah Godugu ₃ , Pramod Kumar Dubey ₂

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2,4-Thiazolidinediones are versatile scaffolds with a unique structural feature of hydrogen bonding donor and the hydrogen bonding acceptor region. This review deals with the synthesis of various bio-active 2,4-thiazolidinedione derivatives. It is presented on the basis of the linker variations at 3rd & 5th positions of 2,4-thizolidinediones. Biological evaluations of various derivatives thus prepared and toxicity studies on the respective products as given by various researchers/ Research groups have been described.

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