Background: The Glassy Carbon Electrode (GCE) was modified with zinc oxide nanoparticles to enhance the electrocatalytic activity of the redox behavior of cefotaxime ion. ATOMIC Force Microscopy (AFM) photographic studies showed the nanorod like structure of the zinc oxide, which was coated uniformly on the electrode surface.

Methods: The zinc oxide nanorod modified electrode was used as novel voltammetric determination of cefotaxime. The results of voltammetric behavior are satisfactory in the electro oxidation of cefotaxime, and exhibit considerable improvement compared to glassy carbon electrode.

Results: Under the optimized experimental conditions, the ZnO nanorod modified electrode exhibit better linear dynamic range from 300 ppb to 700 ppb with lower limit of detection 200 ppb for the stripping voltammetric determination of cefotaxime.

Conclusion: The pharmaceutical and clinical formulation of cefotaxime was successfully applied for accurate determination of trace amounts on ZnO nanomateials modified electrode.

背景：玻碳电极（GCE）用氧化锌纳米粒子改性，以增强头孢噻肟离子的氧化还原行为的电催化活性。ATOMIC力显微镜（AFM）的照相研究显示出氧化锌的纳米棒状结构，该结构均匀地涂覆在电极表面上。

方法：采用氧化锌纳米棒修饰电极作为头孢噻肟的伏安法。伏安行为的结果在头孢噻肟的电氧化中令人满意，并且与玻璃碳电极相比显示出显着的改进。

结果：在最佳实验条件下，ZnO纳米棒修饰电极在300 ppb至700 ppb的线性动态范围内具有较好的线性范围，而下限为200 ppb，用于头孢噻肟的溶出伏安法测定。

结论：头孢噻肟的药物和临床配方已成功用于准确测定ZnO纳米材料修饰电极上的痕量。