Background: There is an increasing demand for innovation in petroleum system replacements. Towards this aim, lignocellulosic biomass is suggested as a possible sustainable source for the manufacturing of fuels and chemical production. This paper aims to investigate different kinds of β-O-4 lignin model compounds for the production of value-added chemicals in the presence of ionic liquids. Especially, cheap β-O-4 lignin model guaiacol glycerol ether (GGE) (Guaifenesin) is introduced to produce valuable chemicals and novel products.

Methods: The research related to chemical depolymerization of lignocellulosic biomass activity is reviewed and an account of different methods such as thermal and microwave for the last 10 years is presented. So, this work provides an excellent background for academic research and it gives an efficient strategy for the manufacturing of novel value-added chemicals at an industrial scale.

Results: The review concludes that ionic liquid microwave-assisted synthesis is a power-saving, cost-efficient, fast reaction, and clean way with high selectively and purity for the production of high-value chemicals rather than conventional heating. Guaiacol and catechol are some of these valuable chemicals produced from β-O-4 lignin model compounds with high demands and large industrial scale prospects.

Conclusion: The β-O-4 lignin model compounds such as guaiacol glycerol ether (GGE) (Guaifenesin) are a good platform for developing food materials, perfumery, biorefinery, and pharmaceutical industry by ionic liquids-assisted lignin depolymerization method.

背景：对石油系统替代品的创新需求不断增加。为实现这一目标，建议木质纤维素生物质作为燃料制造和化学品生产的可能可持续来源。本文旨在研究不同种类的 β-O-4 木质素模型化合物，用于在离子液体存在下生产增值化学品。特别是，引入了廉价的β-O-4木质素模型愈创木酚甘油醚（GGE）（愈创甘油醚）以生产有价值的化学品和新产品。

方法：回顾了与木质纤维素生物质活性化学解聚相关的研究，并介绍了过去 10 年不同的方法，如热和微波。因此，这项工作为学术研究提供了极好的背景，并为以工业规模制造新型增值化学品提供了有效的策略。

结果：该综述的结论是，离子液体微波辅助合成是一种节能、经济、反应快速、清洁的方法，具有高选择性和高纯度，用于生产高价值化学品，而不是常规加热。愈创木酚和儿茶酚是由 β-O-4 木质素模型化合物生产的一些有价值的化学品，具有高需求和大工业规模前景。

结论：β-O-4木质素模型化合物如愈创木酚甘油醚（GGE）（愈创甘油醚）是利用离子液体辅助木质素解聚方法开发食品原料、香料、生物精炼和制药工业的良好平台。