1, 3, 5-Triazine (s-Triazine) is a versatile nucleus to design and develop potent bioactive molecules for drug discovery, particularly in cancer therapy. The aim of this review is to present the most recent trends in the field of synthetic strategies made for functionalized triazine derivatives active against cell proliferation. This review article covers the synthesis of aryl methylamino, morpholino, triamino substituted triazines, antimitotic agents coupled triazines and many more. Many 1,3,5- triazine derivatives, both hetero-fused and uncondensed, have shown remarkable antitumor activities. We have highlighted various derivatives with 1, 3, 5-triazine core targeting different kinases with an aim to help researchers for developing new 1, 3, 5-triazine derived compounds for antitumor activity.

1，3，5-三嗪（s-Triazine）是一种通用核，可用于设计和开发有效的生物活性分子以用于药物发现，尤其是在癌症治疗中。这篇综述的目的是介绍在合成策略领域中针对对细胞增殖具有活性的功能化三嗪衍生物所做的最新趋势。这篇综述文章涵盖了芳基甲基氨基，吗啉代，三氨基取代的三嗪，抗有丝分裂剂偶联的三嗪等的合成。许多1,3,5-三嗪衍生物，无论是杂合的还是未缩合的，都显示出显着的抗肿瘤活性。我们着重介绍了具有1、3、5-三嗪核心的多种衍生物，这些衍生物靶向不同的激酶，目的是帮助研究人员开发新的1、3、5-三嗪衍生的具有抗肿瘤活性的化合物。