Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2020-10-31 , DOI: 10.2174/1570178617666200207110109 Darío A. Vargas 1 , Leticia J. Mendez 1 , Alicia S. Cánepa 1
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A simple and efficient methodology for Friedel-Crafts acylation of 3-methylindole using Amberlyst 15 resin as catalyst is described. This methodology shows good selectivity towards the formation of the products of 2-acylation, (3-methyl-1H-indol-2-yl)ketones. Several advantages can be ascribed to Amberlyst 15, among them; are the ease of handling, quick separation from the reaction mixture and minimum or no production of the chemical residues that must be eliminated. Besides, the catalyst can be easily recycled and reused with a minimal loss in activity through 6 reaction cycles. The catalyst was characterized by FT-IR spectroscopy and superficial acidity.
中文翻译：
使用Amberlyst-15改进3-甲基吲哚的酰化反应
描述了使用Amberlyst 15树脂作为催化剂的3-甲基吲哚的Friedel-Crafts酰化的简单有效方法。该方法显示出对形成2-酰化（3-甲基-1H-吲哚-2-基）酮的产物的良好选择性。Amberlyst 15可归因于以下几个优点：操作简便，与反应混合物的快速分离以及最少或根本没有产生必须消除的化学残留物。此外，该催化剂可以容易地回收和再利用，通过6个反应周期，活性损失最小。通过FT-IR光谱和表面酸性表征了该催化剂。
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