Background: The antioxidant, anticarcinogenic, and antimicrobial activities of Verbascum Thapsus L., known as great mullein, (an important medicinal plant containing different biochemical compounds including sesquiterpenes, flavonoids, saponins and lignins) were determined. There is not much data, to our knowledge, in this respect.

Methods: The antioxidant activities of V. Thapsus were investigated by the DPPH (2, 2- diphenyl- 1-picrylhydrazyl) method. Using GC-MS, the presence of different anticarcinogenic products including 1-hexzanol (2.11%), 2-hexene (1.95%), etc. was determined in the ethanolic extract of V. Thapsus. The antimicrobial activities of V. Thapsus were determined by the minimum inhibiting concentration (MIC) and minimum bactericidal concentration (MBC) methods using the Grampositive and -negative bacterial strains.

Results: The least concentration of V. Thapsus L. ethanolic extract (50 mg/l) resulted in only 21.26% inhibition of DPPH free radicals, however, the concentrations of 300 mg/l resulted in almost the highest inhibition (91.31%) of DPPH free radicals. The antioxidant activities of synthesized antioxidant BHT at the concentration of 300 mg/l or higher were similar to the antioxidant activities of V. Thapsus L. ethanolic extract. Both the isolated and the standard Gram-negative bacterial strains were more tolerant to the V. Thapsus ethanolic extract, compared with the Grampositive bacterial strains. Bacillus cereus was the most sensitive bacterial strain among the tested bacterial strains.

Conclusion: The medicinal plant V. Thapsus L. can be used for the treatment of different diseases, such as cancer and infectious diseases.

背景：测定了被称为大毛蕊花（Verscum Thapsus L.）的毛蕊花（一种重要的药用植物，其中含有不同的生化化合物，包括倍半萜，类黄酮，皂角苷和木质素）的抗氧化，抗癌和抗微生物活性。就我们所知，在这方面没有太多数据。

方法：采用DPPH（2，2-二苯基-1-吡啶并肼基）方法研究了番茄的抗氧化活性。使用GC-MS，在V. Thapsus的乙醇提取物中确定了不同的抗癌产物，包括1-己醇（2.11％），2-己烯（1.95％）等。利用革兰氏阳性和阴性细菌菌株的最低抑菌浓度（MIC）和最低杀菌浓度（MBC）方法确定斜纹夜蛾的抗菌活性。

结果：最小浓度的V. Thapsus L.乙醇提取物（50 mg / l）只能抑制21.26％的DPPH自由基，而300 mg / l的浓度几乎可以导致最高的抑制（91.31％） DPPH自由基。浓度为300 mg / l或更高的合成抗氧化剂BHT的抗氧化活性与V. Thapsus L.乙醇提取物的抗氧化活性相似。与革兰氏阳性菌相比，分离的革兰氏阴性菌和标准革兰氏阴性菌都对番茄斜纹夜蛾的乙醇提取物具有更高的耐受性。蜡状芽孢杆菌是所测试的细菌菌株中最敏感的细菌菌株。

结论：药用植物V. Thapsus L.可用于治疗多种疾病，例如癌症和传染病。