40% aq. HF Catalyzed Three-Component Synthesis of Novel Indeno[1, 2-b][1,8]naphthyridin-6(11H)-one Derivatives and their Antimicrobial Activity,Letters in Organic Chemistry

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40% aq. HF Catalyzed Three-Component Synthesis of Novel Indeno[1, 2-b][1,8]naphthyridin-6(11H)-one Derivatives and their Antimicrobial Activity
Letters in Organic Chemistry ( IF 0.7 ) Pub Date : 2020-12-31 , DOI: 10.2174/1570178617666200210112843
Srinu Bhoomandla ₁ , Phani Raja Kanuparthy ₁ , Rambabu Gundla ₁ , Ramana Reddy Bobbala ₁

Affiliation

A three-component synthesis of novel 5-phenyl-2-(thiophen-2-yl)-4-(trifluoromethyl)-5Hindeno [1,2-b] [1,8] naphthyridin-6(11H)-one derivatives (4a-n) was prepared using 6-phenyl/ (thiophen- 2-yl)-4-(trifluoromethyl)pyridin-2-amine, 1H-indene-1,3(2H)-dione, and aryl aldehyde using 40% aq. HF with good yield. All the synthesized compounds were screened against Gram-positive and Gram-negative bacterial strains and different Candida strains by the well diffusion method. Compounds 4c, 4f, and 4g showed promising activity on Bacillus subtilis strain and compounds 4c and 4g showed promising activity towards Candida albicans strains.

中文翻译：

40％含水 HF催化新型茚并[1,2-b] [1,8]萘啶-6（11H）-one衍生物的三组分合成及其抗菌活性

新的5-苯基-2-（噻吩-2-基）-4-（三氟甲基）-5Hindeno [1,2-b] [1,8]萘啶-6（11H）-一衍生物的三组分合成（使用6-苯基/（噻吩-2-基）-4-（三氟甲基）吡啶-2-胺，1H-茚-1,3（2H）-二酮和芳基醛（使用40％aq）制备4a-n）。HF具有良好的产率。通过孔扩散法对所有合成的化合物针对革兰氏阳性和革兰氏阴性细菌菌株和不同的念珠菌菌株进行了筛选。化合物4c，4f和4g对枯草芽孢杆菌菌株显示出有希望的活性，化合物4c和4g对白色念珠菌菌株显示出有希望的活性。

更新日期：2021-03-09

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