Background: The regulatory function of transcription factors on genes is not only related to the location of binding genes and its related functions, but is also related to the methods of binding.

Objective: It is necessary to study the regulation effects in different binding methods on target genes.

Methods: In this study, we provided a reliable theoretical basis for studying gene expression regulation of co-binding transcription factors and further revealed the specific regulation of transcription factor co-binding in cancer cells.

Results: Transcription factors tend to combine with other transcription factors in the regulatory region to form a competitive or synergistic relationship to regulate target genes accurately.

Conclusion: We found that up-regulated genes in cancer cells were involved in the regulation of their own immune system related to the normal cells.

背景：转录因子对基因的调控功能不仅与结合基因的位置及其相关功能有关，而且与结合方法有关。

目的：有必要研究不同结合方式对靶基因的调控作用。

方法：在这项研究中，我们为研究共结合转录因子的基因表达调控提供了可靠的理论基础，并进一步揭示了癌细胞中转录因子共结合的特异性调控。

结果：转录因子倾向于在调节区域与其他转录因子结合，形成竞争或协同关系，从而精确地调节靶基因。

结论：我们发现癌细胞中上调的基因参与了其自身与正常细胞相关的免疫系统的调节。