Mini-Reviews in Organic Chemistry ( IF 1.9 ) Pub Date : 2020-11-30 , DOI: 10.2174/1570193x17666200220130735 Andrés-Felipe Villamizar-Mogotocoro 1 , Andrés-Felipe León-Rojas 2 , Juan-Manuel Urbina-González 1
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The five-membered oxacyclic system of furan-2(5H)-ones, commonly named as γ- butenolides or appropriately as Δα,β-butenolides, is of high interest since many studies have proven its bioactivity. During the past few years, Δα,β-butenolides have been important synthetic targets, with several reports of new procedures for their construction. A short compendium of the main different synthetic methodologies focused on the Δα,β-butenolide ring formation, along with selected examples of compounds with relevant biological activities of these promising pharmaceutical entities is presented.
中文翻译：
Δα ，β-丁烯内酯[Furan-2（5 H）-ones]：环的构建方法和生物学方面-综述
呋喃-2（5H）-一的五元氧杂环系统通常被称为γ-丁烯内酯或适当地被称为Δα ，β-丁烯内酯，因为许多研究已证明其生物活性。在过去的几年中，Δα ，β-丁烯内酯已成为重要的合成靶标，有关其构建新方法的一些报道。介绍了主要的不同合成方法的简短摘要，重点是Δα ，β-丁烯内酯环的形成，以及具有这些有前途的药物实体的相关生物活性的化合物的选定实例。
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