Solanesol has antibacterial, anticancer, anti-inflammatory and antiulcer biological activities, and is a key intermediate in the synthesis of coenzyme Q10, vitamin K2, and the anticancer synergist N-solanesyl-N,N'-bis(3,4-dimethoxy-benzyl)ethylenediamine (SDB) and other ubiquinone drugs. Due to its unique chemical structure, the chemical synthesis of solanesol is difficult, so solanesol is currently mainly isolated from solanaceous plants. Tobacco (Nicotiana tabacum) has the highest content of solanesol compared to other solanaceous plants. Currently, the research on the extraction of solanesol from tobacco focuses on its extraction and purification. This article reviews the extraction methods, saponification, separation and purification methods of solanesol, as well as the research progress on tobacco solanesol, in China and abroad in recent years. Studies show that the organic solvent extraction method is time-consuming and has a low extraction rate. Modern technology- assisted extraction methods, such as ultrasound-assisted extraction, microwave-assisted extraction, and supercritical carbon dioxide (CO2) extraction not only can improve the extraction rate but also can effectively shorten the extraction time. The separation and purification of solanesol from the extracting solution are critical steps to meet the purity requirements of synthetic drugs, and are also key in limiting the large-scale industrial production of high-purity solanesol. Molecular Imprinting Technology (MIT) has the advantages of small investment, simple operation and ease of large scale production compared to chromatographic methods. Solanesol separated by MIT can meet the requirements for synthesizing coenzyme Q10. Nowadays, the synthesis of molecularly-imprinted solanesol polymers with better adsorption efficiency is one of the important directions in the future research of solanesol purification.

茄尼醇具有抗菌，抗癌，抗炎和抗溃疡的生物学活性，是合成辅酶Q10，维生素K2和抗癌协同剂N-茄尼基-N，N'-双（3,4-二甲氧基-苄基）乙二胺（SDB）和其他泛醌药物。由于其独特的化学结构，茄尼醇的化学合成很困难，因此茄尼醇目前主要从茄科植物中分离出来。与其他茄科植物相比，烟草（Nicotiana tabacum）的茄尼醇含量最高。目前，从烟草中提取茄尼醇的研究集中在其提取和纯化上。本文综述了茄尼醇的提取方法，皂化，分离纯化方法以及烟草茄尼醇的研究进展，近年来在国内外。研究表明，有机溶剂的提取方法耗时且提取率低。超声辅助萃取，微波辅助萃取和超临界二氧化碳（CO2）萃取等现代技术辅助的萃取方法不仅可以提高萃取率，而且可以有效缩短萃取时间。从提取液中分离提纯茄尼醇是满足合成药物纯度要求的关键步骤，也是限制高纯度茄尼醇大规模工业生产的关键。与色谱法相比，分子印迹技术（MIT）具有投资少，操作简单和易于大规模生产的优点。MIT分离得到的茄尼醇可以满足合成辅酶Q10的要求。如今，具有更好吸附效率的分子印迹茄尼醇聚合物的合成是今后茄尼醇纯化研究的重要方向之一。