Background: The microbiome plays a very important role in many physiological processes including metabolism, inflammation, homeostasis and many biological pathways. Therefore, dysbiosis of the microbiome disrupts these pathways in different ways that may result in causing cancer. There is a complex connection between the microbiome and cancer. The human bodies are continuously exposed to microbial cells, both resident and transient, as well as their byproducts, including toxic metabolites.

Objective: To develop the manually curated, searchable and metagenomic resource to facilitate the investigation of Human Cancer microbiota and make it publicly accessible through a web interface which will help further in metagenomic studies.

Methods: In HOBD, the information on different cancers (Oral Cancer, Breast Cancer, Liver Cancer, and Colorectal Cancer) has been compiled. The main purpose of creating HOBD was to provide the scientific community with comprehensive information on the species that play a crucial role in various Human Cancers.

Result: Over time, this resource will grow to become a unique community resource of human cancer bacteria, providing an extra level of annotation for the analysis of metagenomic datasets.

Conclusion: The HOBD site offers easy to use tools for viewing all publicly available Human Cancer microbiota. The freely accessible website is available at http://www.juit.ac.in/hcmd/home.

背景：微生物组在许多生理过程中起着非常重要的作用，包括代谢，炎症，体内平衡和许多生物途径。因此，微生物组的营养不良会以可能导致癌症的不同方式破坏这些途径。微生物组与癌症之间存在复杂的联系。人体持续暴露于常驻和短暂的微生物细胞及其副产物，包括有毒代谢产物。

目的：开发手动管理，可搜索和宏基因组学的资源，以促进人类癌症微生物群的研究，并使其通过网络界面公开访问，这将有助于进一步进行宏基因组学研究。

方法：在HOBD中，已汇编了有关不同癌症（口腔癌，乳腺癌，肝癌和结直肠癌）的信息。建立HOBD的主要目的是向科学界提供有关在各种人类癌症中起关键作用的物种的全面信息。

结果：随着时间的流逝，该资源将增长成为人类癌症细菌的独特社区资源，为宏基因组数据集的分析提供额外的注释。

结论：HOBD网站提供了易于使用的工具来查看所有公开可用的人类癌症菌群。可免费访问的网站位于http://www.juit.ac.in/hcmd/home。