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Neuroproteomics in Paving the Pathway for Drug Abuse Research
Current Proteomics ( IF 0.5 ) Pub Date : 2019-07-31 , DOI: 10.2174/1570164616666181127144621
Muhammad Naveed 1 , Attha Tallat 2 , Ayesha Butt 2 , Maria Khalid 2 , Marium Shehzadi 2 , Nida Bashir 2 , Komal Kafait Ullah Malik 2 , Shafia Tufail 2 , Faisal Nouroz 3
Affiliation  

Neuroproteomics, as a sub-discipline of proteomics, has enlightened the pathway for the study of different complicated diseases and brain disorders. Since four decades, various analytical and quantitative techniques have been used to cure problems related to brain and memory. Brain has a complex structure with various cells and cell types, the expressing proteins and suppressing factors too. Drug addiction is one of the main health concerns as it causes physiological changes in brain and affects its different parts. Some of these drugs like cocaine, marijuana, nicotine and alcohol not only affect memory and brain cells but also lead to expression and suppression of unwanted and beneficial proteins respectively. A variety of techniques involving separation techniques, quantification techniques and analytical techniques are used along with the combination of bioinformatics and magical tools for analyzing different aspects of brain parts especially proteome of the brain cells. Moreover, different animal models preferably those resembling human beings are routinely used in neuroproteomics to study the effects of different drugs on the brain proteome. Different experiments have already been performed by the researchers on drug abuse that helped massively in estimating not only the effects of drug addiction on the brain of highly complex organisms (human beings) but also to propose different therapeutics.



中文翻译:

神经蛋白质组学为药物滥用研究铺平道路

神经蛋白质组学作为蛋白质组学的一个子学科,为研究各种复杂疾病和脑部疾病开辟了道路。四十年以来,已经使用了各种分析和定量技术来解决与大脑和记忆有关的问题。脑部具有复杂的结构,具有各种细胞和细胞类型,表达蛋白质和抑制因子。吸毒成瘾是主要的健康问题,因为它会引起大脑的生理变化并影响其不同部位。其中一些药物,例如可卡因,大麻,尼古丁和酒精,不仅会影响记忆力和脑细胞,还会分别导致有害蛋白质的表达和抑制。涉及分离技术的多种技术,定量技术和分析技术与生物信息学和神奇的工具结合使用,可用于分析脑部各个方面,尤其是脑细胞蛋白质组。此外,在神经蛋白质组学中通常使用不同的动物模型,优选类似于人类的动物模型,以研究不同药物对脑蛋白质组的影响。研究人员已经对药物滥用进行了不同的实验,这些实验不仅极大地估计了药物成瘾对高度复杂生物(人类)的大脑的影响,而且还提出了不同的治疗方法。通常在神经蛋白质组学中使用不同的动物模型,最好是类似于人类的动物模型,以研究不同药物对大脑蛋白质组的影响。研究人员已经对药物滥用进行了不同的实验,这些实验不仅极大地估计了药物成瘾对高度复杂生物(人类)的大脑的影响,而且还提出了不同的治疗方法。通常在神经蛋白质组学中使用不同的动物模型,最好是类似于人类的动物模型,以研究不同药物对大脑蛋白质组的影响。研究人员已经对药物滥用进行了不同的实验,这些实验不仅极大地估计了药物成瘾对高度复杂生物(人类)的大脑的影响,而且还提出了不同的治疗方法。

更新日期:2019-07-31
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