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Supramolecular antibiotics: a strategy for conversion of broad-spectrum to narrow-spectrum antibiotics for Staphylococcus aureus
Nanoscale ( IF 5.8 ) Pub Date : 2020-09-24 , DOI: 10.1039/d0nr04886k Thameez M Koyasseril-Yehiya 1 , Alam García-Heredia 2 , Francesca Anson 1 , Poornima Rangadurai 1 , M Sloan Siegrist 3 , S Thayumanavan 4
Nanoscale ( IF 5.8 ) Pub Date : 2020-09-24 , DOI: 10.1039/d0nr04886k Thameez M Koyasseril-Yehiya 1 , Alam García-Heredia 2 , Francesca Anson 1 , Poornima Rangadurai 1 , M Sloan Siegrist 3 , S Thayumanavan 4
Affiliation
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The propensity of broad-spectrum antibiotics to indiscriminately kill both pathogenic and beneficial bacteria has a profound impact on the spread of resistance across multiple bacterial species. Alternative approaches that narrow antibacterial specificity towards desired pathogenic bacterial population are of great interest. Here, we report an enzyme-responsive antibiotic-loaded nanoassembly strategy for narrow delivery of otherwise broad-spectrum antibiotics. We specifically target Staphylococcus aureus (S. aureus), an important blood pathogen that secretes PC1 β-lactamases. Our nanoassemblies selectively eradicate S. aureus grown in vitro with other bacteria, highlighting its potential capability in targeting the desired pathogenic bacterial population.
中文翻译：
超分子抗生素：金黄色葡萄球菌广谱转窄谱抗生素的策略
广谱抗生素不分青红皂白地杀死病原菌和有益菌的倾向对多种细菌物种的耐药性传播具有深远的影响。将抗菌特异性缩小到所需致病菌群的替代方法引起了人们极大的兴趣。在这里，我们报告了一种酶响应抗生素负载纳米组装策略，用于窄范围递送广谱抗生素。我们专门针对金黄色葡萄球菌( S. aureus )，这是一种分泌 PC1 β-内酰胺酶的重要血液病原体。我们的纳米组件选择性根除体外生长的金黄色葡萄球菌 与其他细菌一起，突出了其针对所需致病菌群的潜在能力。
更新日期：2020-10-08
中文翻译：
超分子抗生素：金黄色葡萄球菌广谱转窄谱抗生素的策略
广谱抗生素不分青红皂白地杀死病原菌和有益菌的倾向对多种细菌物种的耐药性传播具有深远的影响。将抗菌特异性缩小到所需致病菌群的替代方法引起了人们极大的兴趣。在这里，我们报告了一种酶响应抗生素负载纳米组装策略，用于窄范围递送广谱抗生素。我们专门针对金黄色葡萄球菌( S. aureus )，这是一种分泌 PC1 β-内酰胺酶的重要血液病原体。我们的纳米组件选择性根除体外生长的金黄色葡萄球菌 与其他细菌一起，突出了其针对所需致病菌群的潜在能力。
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