Arsenic trioxide has shown a strong anti-tumor effect with little toxicity when used in the treatment of acute promyelocytic leukemia (APL). An effect on glioma has also been shown. Its mechanisms include regulation of apoptosis and autophagy; promotion of the intracellular production of reactive oxygen species, causing oxidative damage; and inhibition of tumor stem cells. However, glioma cells and tissues from other sources show different responses to arsenic trioxide. Researchers are working to enhance its efficacy in anti-glioma treatments and reducing any adverse reactions. Here, we review recent research on the efficacy and mechanisms of action of arsenic trioxide in the treatment of gliomas to provide guidance for future studies.

中文翻译：

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三氧化二砷作为新型抗神经胶质瘤药物：综述

当用于治疗急性早幼粒细胞白血病（APL）时，三氧化二砷已显示出强大的抗肿瘤作用且几乎没有毒性。还显示了对神经胶质瘤的作用。其机制包括调节细胞凋亡和自噬。促进细胞内活性氧的产生，引起氧化损伤；和抑制肿瘤干细胞。但是，来自其他来源的神经胶质瘤细胞和组织对三氧化二砷的反应不同。研究人员正在努力提高其在抗神经胶质瘤治疗中的功效，并减少任何不良反应。在此，我们回顾了有关三氧化二砷在神经胶质瘤治疗中的功效和作用机理的最新研究，为将来的研究提供指导。