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The Applications of Carbon Nanotubes in the Diagnosis and Treatment of Lung Cancer: A Critical Review
International Journal of Nanomedicine ( IF 6.6 ) Pub Date : 2020-09-24 , DOI: 10.2147/ijn.s263238
Mojgan Sheikhpour , Maryam Naghinejad , Alibakhsh Kasaeian , Armaghan Lohrasbi , Seyed Sadegh Shahraeini , Shahab Zomorodbakhsh

Abstract: The importance of timely diagnosis and the complete treatment of lung cancer for many people with this deadly disease daily increases due to its high mortality. Diagnosis and treatment with helping the nanoparticles are useful, although they have reasonable harms. This article points out that the side effects of using carbon nanotube (CNT) in this disease treatment process such as inflammation, fibrosis, and carcinogenesis are very problematic. Toxicity can reduce to some extent using the techniques such as functionalizing to proper dimensions as a longer length, more width, and greater curvature. The targeted CNT sensors can be connected to various modified vapors. In this regard, with helping this method, screening makes non-invasive diagnosis possible. Researchers have also found that nanoparticles such as CNTs could be used as carriers to direct drug delivery, especially with chemotherapy drugs. Most of these carriers were multi-wall carbon nanotubes (MWCNT) used for cancerous cell targeting. The results of laboratory and animal researches in the field of diagnosis and treatment became very desirable and hopeful. The collection of researches summarized has highlighted the requirement for a detailed assessment which includes CNT dose, duration, method of induction, etc., to achieve the most controlled conditions for animal and human studies. In the discussion section, 4 contradictory issues are discussed which are invited researchers to do more research to get clearer results.

Keywords: carbon nanotubes, toxicity, lung cancer detection, lung cancer treatment, drug delivery


中文翻译:

碳纳米管在肺癌诊断和治疗中的应用:综述。

摘要:由于这种致命性疾病的高死亡率,对于许多每天都有这种致命疾病的人,及时诊断和彻底治疗肺癌的重要性日益增加。尽管有合理的危害,但有助于纳米颗粒的诊断和治疗还是有用的。本文指出,在这种疾病的治疗过程中使用碳纳米管(CNT)的副作用,例如炎症,纤维化和致癌作用,是非常成问题的。使用诸如功能化为适当的尺寸(例如更长的长度,更大的宽度和更大的曲率)的技术,毒性可以在某种程度上降低。目标CNT传感器可以连接到各种改性蒸汽。在这方面,借助这种方法,筛查可以进行非侵入性诊断。研究人员还发现,诸如CNTs的纳米粒子可以用作指导药物输送的载体,尤其是化学疗法药物。这些载体大多数是用于癌细胞靶向的多壁碳纳米管(MWCNT)。在诊断和治疗领域的实验室和动物研究的结果变得非常令人希望和充满希望。汇总的研究成果突出了对详细评估的要求,其中包括CNT剂量,持续时间,诱导方法等,以实现动物和人类研究的最可控条件。在讨论部分,讨论了4个矛盾的问题,邀请研究人员进行更多研究以获得更清晰的结果。这些载体大多数是用于癌细胞靶向的多壁碳纳米管(MWCNT)。在诊断和治疗领域的实验室和动物研究的结果变得非常令人希望和充满希望。汇总的研究成果突出了对详细评估的要求,其中包括CNT剂量,持续时间,诱导方法等,以实现动物和人类研究的最可控条件。在讨论部分,讨论了4个矛盾的问题,邀请研究人员进行更多研究以获得更清晰的结果。这些载体大多数是用于癌细胞靶向的多壁碳纳米管(MWCNT)。在诊断和治疗领域的实验室和动物研究的结果变得非常令人希望和充满希望。汇总的研究成果突出了对详细评估的要求,其中包括CNT剂量,持续时间,诱导方法等,以实现动物和人类研究的最可控条件。在讨论部分,讨论了4个矛盾的问题,邀请研究人员进行更多研究以获得更清晰的结果。汇总的研究成果突出了对详细评估的要求,其中包括CNT剂量,持续时间,诱导方法等,以实现动物和人类研究的最可控条件。在讨论部分,讨论了4个矛盾的问题,邀请研究人员进行更多研究以获得更清晰的结果。汇总的研究成果突出了对详细评估的要求,其中包括CNT剂量,持续时间,诱导方法等,以实现动物和人类研究的最可控条件。在讨论部分,讨论了4个矛盾的问题,邀请研究人员进行更多研究以获得更清晰的结果。

关键词:碳纳米管毒性肺癌检测肺癌治疗药物输送
更新日期:2020-09-24
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