Background. Drug-drug interactions (DDIs) are a common issue that leads to adverse drug reactions in hospitals. Patients in the surgical department are expected to have potential DDIs that may lead to morbidity and mortality. Objectives. To study potential DDI prevalence in the surgery departments in 3 hospitals in Palestine. Moreover, to identify pertinent factors that are associated with drug-drug interactions. Method. A cross-sectional study in 3 governmental Palestinian hospitals: Palestine Medical Complex, Rafidia Hospital, and Beit Jala Hospital. Patients who are 20 years old or above and admitted to the surgical wards between September 2017 and February 2018 were included in the study. Patient demographics, all medications given in the hospital, and hospitalization period were obtained from medical files. The digital clinical decision support system Micromedex® was used for analysis and classification of possible drug interactions. Bivariate analysis and logistic regression were used to study the risk factors for developing DDIs. Results. 502 patients were included in this report. The prevalence of potential DDIs among patients admitted to surgery wards in three Palestinian hospitals was 56%. The number of detected potential DDIs per patient was . The number of prescribed medications () was found to increase the possibility of having drug interactions. Conclusions. DDIs in Palestinian hospitals are a prevalent problem, and caution should be taken when ordering medications to hospitalized patients in surgery departments.

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评估三家巴勒斯坦医院外科住院患者之间的药物-药物相互作用潜力

背景。药物-药物相互作用 (DDI) 是导致医院药物不良反应的常见问题。外科部门的患者预计会有可能导致发病率和死亡率的潜在 DDI。目标。研究巴勒斯坦 3 家医院外科部门潜在的 DDI 患病率。此外，确定与药物-药物相互作用相关的相关因素。方法. 在 3 家政府巴勒斯坦医院进行的横断面研究：巴勒斯坦医疗中心、拉菲迪亚医院和贝特贾拉医院。2017 年 9 月至 2018 年 2 月期间入住外科病房的 20 岁或以上患者纳入研究。从医疗档案中获得患者人口统计数据、医院给予的所有药物和住院时间。数字临床决策支持系统 Micromedex® 用于分析和分类可能的药物相互作用。双变量分析和逻辑回归用于研究发生 DDI 的危险因素。结果. 502 名患者被纳入本报告。巴勒斯坦三所医院外科病房收治的患者中潜在 DDI 的患病率为 56%。每名患者检测到的潜在 DDI 数量为. 处方药数量（)被发现会增加药物相互作用的可能性。结论。巴勒斯坦医院的 DDI 是一个普遍存在的问题，在为外科部门的住院患者订购药物时应谨慎。