Objectives. Retina abnormalities are related to cognitive disorders in patients with Alzheimer’s disease (AD). Retinal amyloid beta (Aβ) can be labeled by curcumin. We measured Aβ content in the cerebrum and retina of APPswe/PS1dE9 (APP) transgenic mice with early age to investigate the correlation between cerebrum and retina. Methods. APP mice and age-matched wild-type mice were investigated every month from age 2 months to 6 months to assess changes in Aβ content in the retina and cerebrum. At the beginning of each month, mice were fed a curcumin diet (50 mg/kg/day) for 7 consecutive days. The Aβ levels in the retina and cerebrum were measured by ELISAs. Correlations were identified between retinal and cerebral Aβ contents using Pearson’s correlation. Results. In the absence of curcumin, there was a significant correlation between Aβ contents in the retina and cerebrum of APP mice (, ). With increasing age, Aβ-mediated degenerative change in the cerebrum ( in 5 months) and retina ( in 5 months) increased significantly. The inhibitory effect of curcumin on the Aβ level was significant in the cerebrum () and retina () of older APP mice in the early stage of life. Conclusion. We observed a significant correlation between the Aβ content in the retina and Aβ content in the cerebrum of APP mice. Our data suggest an appropriate time to measure retinal Aβ. Although curcumin can label Aβ in the retina, it also suppresses Aβ levels and weakens the degree of correlation between Aβ in cerebrum and retina tissues.

中文翻译：

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阿尔茨海默病发病前年轻 APPswe/PS1dE9 转基因小鼠的视网膜 β 淀粉样蛋白水平与大脑中 β 淀粉样蛋白水平相关

目标。视网膜异常与阿尔茨海默病 (AD) 患者的认知障碍有关。姜黄素可以标记视网膜淀粉样蛋白β (A β )。我们测量了早期 APPswe/PS1dE9 (APP) 转基因小鼠大脑和视网膜中A β的含量，以研究大脑和视网膜之间的相关性。方法。APP 小鼠和年龄匹配的野生型小鼠在 2 个月至 6 个月大期间每月进行一次调查，以评估视网膜和大脑中 A β含量的变化。在每个月初，连续 7 天给小鼠喂食姜黄素饮食（50 mg/kg/天）。Aβ _通过ELISA测量视网膜和大脑中的水平。使用 Pearson 相关性确定视网膜和大脑 A β含量之间的相关性。结果。在没有姜黄素的情况下，APP小鼠视网膜和大脑中Aβ含量之间存在显着相关性（, ）。随着年龄的增长，Aβ介导的大脑退行性变化（5 个月内）和视网膜（5 个月内）显着增加。姜黄素对大脑中 A β水平的抑制作用显着（)和视网膜 ()生命早期的老年 APP 小鼠。结论。我们观察到视网膜中Aβ含量与大脑中Aβ含量之间存在显着相关性。我们的数据表明测量视网膜 A β的适当时间。虽然姜黄素可以标记视网膜中的 A β，但它也抑制 A β水平并削弱大脑和视网膜组织中A β之间的相关程度。