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Influence of Ions and pH on the Formation of Solid- and Liquid-like Melanin
ACS Omega ( IF 3.7 ) Pub Date : 2020-09-23 , DOI: 10.1021/acsomega.0c01953
Yi-chieh Chen 1 , Thomas Kendall 1 , Philip Yip 2, 3 , Alastair Davy 3 , Jan Sefcik 1 , Jens U. Sutter 3
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Melanin is a natural pigment with broadband absorption and effective ability to dissipate the energy absorbed. The macromolecular structure of melanin shows a delicate balance between short-range ordered and disordered structures without being a random aggregate. The presence of ions or the variation in pH or ionic strength can alter the self-assembly process which subsequently changes the structure of melanin. To understand these relationships, this study investigates the influence of ions and pH in melanin formation. The types of ions present and pH have a profound influence on the formation and structure of melanin particles, while only minor changes are observed in the absorption and excitation–emission analysis. In some conditions, the formation of discernible particles with significant refractive index contrast is avoided while retaining the spectroscopic characteristics of melanin, leading to liquid-like melanin. These findings identify potential pathways which can be used to manipulate the melanin macromolecular structure while providing the desired spectral properties to enable novel bio-engineering applications.

中文翻译:

离子和pH值对固态和液态黑色素形成的影响

黑色素是一种天然色素,具有宽带吸收能力和有效消散吸收能量的能力。黑色素的大分子结构在短程有序结构和无序结构之间显示出微妙的平衡,而并非随机聚集。离子的存在或pH值或离子强度的变化会改变自组装过程,从而改变黑色素的结构。为了理解这些关系,本研究调查了离子和pH对黑色素形成的影响。存在的离子类型和pH值对黑色素颗粒的形成和结构具有深远的影响,而在吸收和激发-发射分析中仅观察到很小的变化。在某些情况下 在保留黑色素的光谱特性的同时,避免了形成具有明显折射率对比的可辨别颗粒,从而形成了液体状黑色素。这些发现确定了可用于操纵黑色素大分子结构,同时提供所需光谱特性以实现新型生物工程应用的潜在途径。
更新日期:2020-10-06
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