Taraxacum syriacum (TS) with natural antioxidant and pharmacological activities may be considered for treatment of oxidative stress induced by acetaminophen (APAP). The aim of this study was to evaluate the ameliorative effects of the ethanol extract of TS root against hepatorenal toxicity induced by APAP in comparison to N-acetylcysteine (NAC) as a standard drug. Thirty male Wistar rats were randomly divided into five groups. Control group; APAP (1 g/kg) group; APAP–NAC (160 mg/kg) group and APAP-TS100 and APAP-TS200 groups: APAP plus 100 and 200 mg/kg of TS extract, respectively. After 7 days treatment, serum and liver and kidney tissues were prepared and evaluated. TS extract ameliorated the increased lipid peroxidation level and decreased antioxidant enzymes activities and glutathione level in liver and kidney of APAP-treated rats. Moreover, treatment with the TS extract caused significant reduction in the histopathological damages and high levels of serum biochemical markers of hepatic and renal functions after APAP treatment. This study suggests that the extract of TS roots has dose-dependent ameliorative effect against APAP-induced oxidative damage in liver and kidney due to its free radical scavenging and antioxidant properties. The overall efficacy of the extract at 200 mg/kg dose is comparable with NAC.

中文翻译：

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蒲公英和N-乙酰半胱氨酸改善对乙酰氨基酚诱导的大鼠肝脏和肾脏氧化应激的改善作用比较

可以考虑使用具有天然抗氧化剂和药理活性的蒲公英（TS）来治疗对乙酰氨基酚（APAP）诱导的氧化应激。这项研究的目的是评估与标准药物N-乙酰半胱氨酸（NAC）相比，TS根乙醇提取物对APAP诱导的肝肾毒性的改善作用。将三十只雄性Wistar大鼠随机分为五组。控制组; APAP（1 g / kg）组；APAP–NAC（160 mg / kg）组以及APAP-TS100和APAP-TS200组：APAP分别加100和200 mg / kg的TS提取物。治疗7天后，制备并评估血清，肝和肾组织。TS提取物改善了APAP治疗的大鼠肝脏和肾脏中脂质过氧化水平的增加，脂质过氧化水平的降低，抗氧化酶活性和谷胱甘肽水平的降低。而且，TS提取物治疗APAP后，可显着减少组织病理学损害，并具有高水平的肝和肾功能血清生化标志物。这项研究表明，TS根提取物具有自由基清除和抗氧化特性，因此对APAP诱导的肝肾氧化损伤具有剂量依赖性的改善作用。提取物在200 mg / kg剂量下的总体功效与NAC相当。这项研究表明，TS根提取物具有自由基清除和抗氧化特性，因此对APAP诱导的肝肾氧化损伤具有剂量依赖性的改善作用。提取物在200 mg / kg剂量下的总体功效与NAC相当。这项研究表明，TS根提取物具有自由基清除和抗氧化特性，因此对APAP诱导的肝肾氧化损伤具有剂量依赖性的改善作用。提取物在200 mg / kg剂量下的总体功效与NAC相当。