Abstract

One of the fastest-moving fields in today’s world of applied science, nanotechnology allows the control and design of matter on an extremely small scale, so it has now become an integral part of various industries and scientific areas, such as agriculture, food sector, healthcare and engineering. Understanding the interactions between nanopesticides and edible plants, as well as non-target animals, is crucial in assessing the potential impact of nanotechnology products on the environment, agriculture and human health. The dramatic increase in efforts to use nanopesticides renders the risk assessment of their toxicity and genotoxicity highly crucial due to the potential adverse impact of this relatively uncharted territory. Such widespread use naturally increases our exposure to nanopesticides, raising concerns over their possible adverse effects on humans and non-target organisms, which might include severe impairment of both male and female reproductive capacity. We therefore need better insight into such effects to derive conclusive evidence on the safety or toxicity/genotoxicity of nanopesticides, and Drosophila melanogaster (fruit fly) can prove an ideal model organism for the risk assessment and toxicological classification of nanopesticides, as it bears striking similarities to various systems in human body. This editorial review attempts to summarize our current knowledge derived from previous in vivo studies to examine the impact of several nanomaterials on various species of mammals and non-target model organisms at the genetic, cellular, and molecular levels, attracting attention to the possible mechanisms and potential toxic/genotoxic effects of nanopesticides widely used in agriculture on D. melanogaster as a non-target organism.

摘要

纳米技术是当今应用科学世界中发展最快的领域之一，它可以非常小规模地控制和设计物质，因此，纳米技术已成为各种行业和科学领域（如农业，食品，医疗保健和工程。了解纳米农药与食用植物以及非目标动物之间的相互作用，对于评估纳米技术产品对环境，农业和人类健康的潜在影响至关重要。由于这种相对未知的领域的潜在不利影响，使用纳米农药的努力的急剧增加使得对其毒性和遗传毒性的风险评估变得至关重要。这种广泛的使用自然增加了我们对纳米农药的暴露，人们担心它们可能对人类和非目标生物造成不利影响，其中可能包括严重损害男性和女性的生殖能力。因此，我们需要对此类效应有更深入的了解，以得出有关纳米农药的安全性或毒性/遗传毒性的确凿证据，以及果蝇（果蝇）可以证明是用于纳米农药的风险评估和毒理学分类的理想模型生物，因为它与人体各种系统具有惊人的相似性。这篇社论评论试图总结我们从先前的体内研究中获得的当前知识，以研究几种纳米材料在遗传，细胞和分子水平上对哺乳动物和非靶标生物体的各种物种的影响，引起人们对可能机制和机制的关注。广泛用于农业的纳米农药作为非目标生物对黑腹果蝇的潜在毒性/遗传毒性作用。