ABSTRACT

Introduction

Nanocarrier-based delivery systems offer multiple benefits to overcome limitations of the traditional drug dosage forms, such as protection of the drug, enhanced bioavailability, targeted delivery to disease site, etc. Nanocarriers have exhibited tremendous successes in targeted delivery of therapeutics to the desired tissues and cells with improved bioavailability, high drug loading capacity, enhanced intracellular delivery, and better therapeutic effect. A specific design of stimuli-responsive nanocarriers allows for changing their structural and physicochemical properties in response to exogenous and endogenous stimuli. These nanocarriers show a promise in site specific controlled release of therapeutics under certain physiological conditions or external stimuli.

Areas covered

This review highlights recent progresses on the multifunctional and stimuli-sensitive nanocarriers for targeted therapeutic drug delivery applications.

Expert opinion

The progress from single functional to multifunctional nanocarriers has shown tremendous potential for targeted delivery of therapeutics. On our opinion, the future of targeted delivery of drugs, nucleic acids, and other substances belongs to the site-targeted multifunctional and stimuli-based nanoparticles with controlled release. Targeting of nanocarriers to the disease site enhance the efficacy of the treatment by delivering more therapeutics specifically to the affected cells and substantially limiting adverse side effects upon healthy organs, tissues, and cells.

中文翻译：

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用于靶向治疗递送的多功能和刺激响应纳米载体

摘要

介绍

基于纳米载体的递送系统具有多种优点，可以克服传统药物剂型的局限性，例如保护药物、增强生物利用度、靶向递送至疾病部位等。纳米载体在将治疗药物靶向递送至所需组织方面取得了巨大成功细胞生物利用度提高，载药量高，细胞内递送增强，治疗效果更好。刺激响应纳米载体的特定设计允许改变其结构和物理化学性质以响应外源和内源刺激。这些纳米载体有望在某些生理条件或外部刺激下实现治疗药物的位点特异性控制释放。

覆盖领域

本综述重点介绍了用于靶向治疗药物输送应用的多功能和刺激敏感纳米载体的最新进展。

专家意见

从单一功能纳米载体到多功能纳米载体的进展显示出靶向治疗药物的巨大潜力。我们认为，药物、核酸和其他物质靶向递送的未来属于定点多功能、基于刺激的控释纳米颗粒。将纳米载体靶向疾病部位，通过向受影响的细胞提供更多的治疗药物，并显着限制对健康器官、组织和细胞的不良副作用，从而增强治疗效果。