Abstract

Ibuprofen is a commonly used non-steroidal anti-inflammatory drug that is noted for its favorable safety profile. It exerts its therapeutic effect through inhibition of prostaglandin (PG) production at inflammatory sites. However, the inhibition of PG synthesis at other sites is responsible for the occurrence of adverse events. Evidence regarding the effect of regular ibuprofen intake on penile PG homeostasis or penile histopathologic changes is lacking. The aim of this study was to examine the effect of regular administration of analgesic therapeutic doses of ibuprofen on penile PG E1 and F2α and penile microscopic changes of the treated rats. This study included four groups of adult male Wistar rats; a control group (I) injected intraperitoneally with saline (2 ml/kg/day) for 30 days and 3 ibuprofen-treated groups (IIa, IIb, and IIc) injected intraperitoneally with 6 mg/kg/day, 12 mg/kg/day, and 18 mg/kg/day ibuprofen, respectively, for 30 days, respectively. Mean levels of penile PGE1 and PGF2α in the control group were significantly higher than ibuprofen-treated groups IIa, IIb, and IIc. The percentage area of collagen around cavernous tissue was significantly higher in ibuprofen-treated groups IIa, IIb, and IIc than control rats. Our findings suggest that despite ibuprofen’s safety profile, regular use of ibuprofen is associated with reduced penile PG and increased cavernosal fibrosis.

摘要

布洛芬是一种常用的非甾体抗炎药，以其良好的安全性而著称。它通过抑制炎症部位的前列腺素 (PG) 产生来发挥其治疗作用。然而，其他位点PG合成的抑制是不良事件发生的原因。缺乏关于定期摄入布洛芬对阴茎 PG 稳态或阴茎组织病理学变化影响的证据。本研究的目的是检查定期给予镇痛治疗剂量的布洛芬对治疗大鼠阴茎 PG E1 和 F2α 和阴茎微观变化的影响。这项研究包括四组成年雄性 Wistar 大鼠；对照组 (I) 腹腔注射生理盐水 (2 ml/kg/天) 30 天，3 个布洛芬治疗组 (IIa, IIb, 和 IIc) 分别以 6 mg/kg/天、12 mg/kg/天和 18 mg/kg/天布洛芬腹膜内注射，分别持续 30 天。对照组阴茎 PGE1 和 PGF2α 的平均水平显着高于布洛芬治疗组 IIa、IIb 和 IIc。在布洛芬治疗组 IIa、IIb 和 IIc 中海绵组织周围胶原的百分比面积显着高于对照组大鼠。我们的研究结果表明，尽管布洛芬具有安全性，但经常使用布洛芬与减少阴茎 PG 和增加海绵体纤维化有关。在布洛芬治疗组 IIa、IIb 和 IIc 中海绵组织周围胶原的百分比面积显着高于对照组大鼠。我们的研究结果表明，尽管布洛芬具有安全性，但经常使用布洛芬与减少阴茎 PG 和增加海绵体纤维化有关。在布洛芬治疗组 IIa、IIb 和 IIc 中海绵组织周围胶原的百分比面积显着高于对照组大鼠。我们的研究结果表明，尽管布洛芬具有安全性，但经常使用布洛芬与减少阴茎 PG 和增加海绵体纤维化有关。