Coronavirus disease 2019 (COVID-19) poses an unprecedented challenge to world health systems substantially increasing hospitalization and mortality rates in all affected countries. Being primarily a respiratory disease, COVID-19 is mainly associated with pneumonia or minor upper respiratory tract symptoms; however, different organs can sustain considerable (if not terminal) damage because of coronavirus. Acute kidney injury (AKI) is the most common complication of COVID-19-related pneumonia and more than 20% of patients requiring ventilatory support develop renal failure. Additionally, chronic kidney disease (CKD) is a major risk factor for COVID-19 severity and mortality. All these data demonstrate the relevance of renal function assessment in COVID-19 patients and the need of early kidney-directed diagnostic and therapeutic approaches. However, the sole assessment of renal function could be not entirely indicative of kidney tissue status. In this viewpoint, we argument about the clinical significance and the potential relevance of renal functional reserve evaluation in COVID-19 patients.

中文翻译：

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呼吁采取行动评估 COVID-19 患者的肾功能储备。


2019 年冠状病毒病 (COVID-19) 对世界卫生系统提出了前所未有的挑战，大幅增加了所有受影响国家的住院率和死亡率。 COVID-19 主要是一种呼吸道疾病，主要与肺炎或轻微的上呼吸道症状有关；然而，由于冠状病毒，不同的器官可能会遭受相当大的（如果不是致命的）损害。急性肾损伤 (AKI) 是 COVID-19 相关肺炎最常见的并发症，超过 20% 需要通气支持的患者会出现肾功能衰竭。此外，慢性肾脏病 (CKD) 是导致 COVID-19 严重程度和死亡率的主要危险因素。所有这些数据都证明了 COVID-19 患者肾功能评估的相关性以及早期针对肾脏的诊断和治疗方法的必要性。然而，肾功能的唯一评估并不能完全表明肾组织状态。本着这一观点，我们讨论了 COVID-19 患者肾功能储备评估的临床意义和潜在相关性。