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Human Salmonella Typhi exposure generates differential multifunctional cross‐reactive T‐cell memory responses against Salmonella Paratyphi and invasive nontyphoidal Salmonella
Clinical & Translational Immunology ( IF 4.6 ) Pub Date : 2020-09-24 , DOI: 10.1002/cti2.1178
Rekha R Rapaka 1, 2 , Rezwanul Wahid 1, 3 , Stephanie Fresnay 1, 3, 4 , Jayaum S Booth 1, 3 , Thomas C Darton 5, 6 , Claire Jones 5 , Claire S Waddington 5, 7 , Myron M Levine 1, 2, 3 , Andrew J Pollard 5 , Marcelo B Sztein 1, 2, 3
Affiliation  

There are no vaccines for most of the major invasive Salmonella strains causing severe infection in humans. We evaluated the specificity of adaptive T memory cell responses generated after Salmonella Typhi exposure in humans against other major invasive Salmonella strains sharing capacity for dissemination.

中文翻译:

人类伤寒沙门氏菌暴露对副伤寒沙门氏菌和侵袭性非伤寒沙门氏菌产生不同的多功能交叉反应性 T 细胞记忆反应

大多数主要的侵入性沙门氏菌菌株都没有疫苗,可导致人类严重感染。我们评估了人类接触伤寒沙门氏菌后产生的适应性 T 记忆细胞反应与其他主要侵入性沙门氏菌菌株共享传播能力的特异性。
更新日期:2020-09-24
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