Envisioning emerging frontiers on human gut microbiota and its applications,Microbial Biotechnology

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Envisioning emerging frontiers on human gut microbiota and its applications
Microbial Biotechnology ( IF 4.8 ) Pub Date : 2020-09-24 , DOI: 10.1111/1751-7915.13671
Marco Ventura _{1,

2} , Christian Milani _{1,

2} , Francesca Turroni _{1,

2} , Douwe van Sinderen ₃

Affiliation

The human gut microbiota is involved in multiple health‐influencing host interactions during the host’s entire life span. Microbes colonize the infant gut instantaneously after birth and subsequently the founding and interactive progress of this early gut microbiota is considered to be driven and modulated by different host‐ and microbe‐associated forces. A rising number of studies propose that the composition of the human gut microbiota in the early stages of life impact on the human health conditions at later stages of life. This notion has powered research aimed at detailed investigations of the infant gut microbiota composition. Nevertheless, the molecular mechanisms supporting the gut microbiome functionality and the interaction of the early gut microbes with the human host remain largely unknown.

中文翻译：

展望人类肠道微生物群及其应用的新兴前沿

在宿主的整个生命周期中，人类肠道微生物群参与多种影响宿主健康的相互作用。微生物在出生后立即在婴儿肠道中定殖，随后这种早期肠道微生物群的建立和相互作用进展被认为是由不同的宿主和微生物相关力驱动和调节的。越来越多的研究表明，生命早期阶段的人类肠道微生物群的组成会影响生命后期的人类健康状况。这一概念推动了旨在详细调查婴儿肠道微生物群组成的研究。然而，支持肠道微生物组功能以及早期肠道微生物与人类宿主相互作用的分子机制仍然很大程度上未知。

更新日期：2020-09-24

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