Current Understanding toward Isonitrile Group Biosynthesis and Mechanism,Chinese Journal of Chemistry

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Current Understanding toward Isonitrile Group Biosynthesis and Mechanism
Chinese Journal of Chemistry ( IF 5.5 ) Pub Date : 2020-09-24 , DOI: 10.1002/cjoc.202000448
Tzu-Yu Chen ₁ , Jinfeng Chen ₂ , Yijie Tang ₃ , Jiahai Zhou _{2,

4} , Yisong Guo ₃ , Wei-Chen Chang ₁

Affiliation

Isonitrile group has been identified in many natural products. Due to the broad reactivity of N≡C triple bond, these natural products have valuable pharmaceutical potentials. This review summarizes the current biosynthetic pathways and the corresponding enzymes that are responsible for isonitrile‐containing natural product generation. Based on the strategies utilized, two fundamentally distinctive approaches are discussed. In addition, recent progress in elucidating isonitrile group formation mechanisms is also presented.

中文翻译：

异腈基团生物合成及机制的最新认识

异腈基团已在许多天然产物中得到鉴定。由于 N−C 三键的广泛反应性，这些天然产物具有宝贵的药物潜力。这篇综述总结了当前的生物合成途径和负责含异腈天然产物生成的相应酶。根据所使用的策略，讨论了两种根本不同的方法。此外，还介绍了阐明异腈基团形成机制的最新进展。

更新日期：2020-09-24

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