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In Vitro Studies of Fe3O4‐ZIF‐8 Core–Shell Nanoparticles Designed as Potential Theragnostics
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-09-23 , DOI: 10.1002/ppsc.202000185 Romy Ettlinger 1 , Natalia Moreno 2 , Natalia Ziółkowska 3 , Aladin Ullrich 4 , Hans‐Albrecht Krug von Nidda 5 , Daniel Jirák 3, 6 , Kornelius Kerl 2 , Hana Bunzen 1
Particle & Particle Systems Characterization ( IF 2.7 ) Pub Date : 2020-09-23 , DOI: 10.1002/ppsc.202000185 Romy Ettlinger 1 , Natalia Moreno 2 , Natalia Ziółkowska 3 , Aladin Ullrich 4 , Hans‐Albrecht Krug von Nidda 5 , Daniel Jirák 3, 6 , Kornelius Kerl 2 , Hana Bunzen 1
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Theragnostics represent a combination of therapy and diagnosis within one system. Herein, Fe3O4‐ZIF‐8 core–shell nanoparticles are developed and suggested as candidates for theragnostic applications in cancer treatment. A drug loaded metal–organic framework ZIF‐8 (zeolitic imidazolate framework‐8) represents the therapeutic tool, while the Fe3O4 core is included to enable the material visualization by magnetic resonance imaging (MRI). A reliable synthesis of Fe3O4‐ZIF‐8 core–shell nanoparticles of an average size below 100 nm is reported. The nanoparticles are characterized by FT‐IR, TGA, XRPD, TEM, STEM‐EDS, DLS, ICP‐OES, CHN‐elemental analysis, SQUID measurements, and MRI. Moreover, their chemical stability and in vitro cytotoxicity against fibroblast and selected cancer cell lines are evaluated. As a model drug, arsenic trioxide—a promising anticancer drug—is used. The drug release can be triggered by a pH change from 7.4 to 6.0 and the nanoparticles can be visualized by MRI in vitro, thus a potential theragnostic agent for cancer treatment is developed.
中文翻译：
Fe3O4-ZIF-8核壳纳米粒子的体外研究设计为潜在的修复技术
Theragnostics代表了一个系统内治疗和诊断的结合。在此，开发了Fe 3 O 4 -ZIF-8核壳纳米粒子，并建议将其用作治疗鼻咽癌的候选药物。载有药物的金属有机框架ZIF-8（沸石咪唑框架8）代表治疗工具，而其中包含的Fe 3 O 4核可通过磁共振成像（MRI）进行材料可视化。可靠地合成Fe 3 O 4报告了平均尺寸低于100 nm的‐ZIF-8核壳纳米粒子。纳米颗粒的特征在于FT-IR，TGA，XRPD，TEM，STEM-EDS，DLS，ICP-OES，CHN元素分析，SQUID测量和MRI。此外，评估了它们对成纤维细胞和所选癌细胞系的化学稳定性和体外细胞毒性。作为模型药物，使用了有希望的抗癌药三氧化二砷。pH值从7.4变为6.0可以触发药物释放，并且可以通过MRI在体外观察纳米颗粒，因此开发了一种潜在的治疗恶性肿瘤的药物。
更新日期：2020-09-23
中文翻译：
Fe3O4-ZIF-8核壳纳米粒子的体外研究设计为潜在的修复技术
Theragnostics代表了一个系统内治疗和诊断的结合。在此，开发了Fe 3 O 4 -ZIF-8核壳纳米粒子，并建议将其用作治疗鼻咽癌的候选药物。载有药物的金属有机框架ZIF-8（沸石咪唑框架8）代表治疗工具，而其中包含的Fe 3 O 4核可通过磁共振成像（MRI）进行材料可视化。可靠地合成Fe 3 O 4报告了平均尺寸低于100 nm的‐ZIF-8核壳纳米粒子。纳米颗粒的特征在于FT-IR，TGA，XRPD，TEM，STEM-EDS，DLS，ICP-OES，CHN元素分析，SQUID测量和MRI。此外，评估了它们对成纤维细胞和所选癌细胞系的化学稳定性和体外细胞毒性。作为模型药物，使用了有希望的抗癌药三氧化二砷。pH值从7.4变为6.0可以触发药物释放，并且可以通过MRI在体外观察纳米颗粒，因此开发了一种潜在的治疗恶性肿瘤的药物。
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