Damage to enteric neurons and impaired gastrointestinal muscle contractions cause motility disorders in 70% of diabetic patients. It is thought that enteric neuropathy and dysmotility occur before overt diabetes, but triggers of these abnormalities are not fully known. We tested the hypothesis that intestinal contents of mice with and without high‐fat diet‐ (HFD‐) induced diabetic conditions contain molecules that impair gastrointestinal movements by damaging neurons and disrupting muscle contractions.

中文翻译：

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喂食高脂肪饮食的小鼠肠腔内容物的上清液通过损伤肠神经元和平滑肌细胞来损害肠道运动。

肠道神经元受损和胃肠道肌肉收缩受损导致 70% 的糖尿病患者运动障碍。人们认为肠神经病变和运动障碍发生在明显的糖尿病之前，但这些异常的触发因素尚不完全清楚。我们测试了以下假设：有和没有高脂肪饮食 (HFD) 诱导的糖尿病疾病的小鼠的肠道内容物含有通过破坏神经元和破坏肌肉收缩来损害胃肠运动的分子。