As a distinctive population of leucocytes, innate lymphoid cells (ILCs) participate in immune‐mediated diseases and play crucial roles in tissue remodelling after injury. ILC lineages can be divided into helper ILCs and cytotoxic ILCs. Most helper ILCs are integrated into the fabric of tissues and produce different types of cytokines involving in the pathogenesis of many kinds of cardiovascular disease and form intricate response circuits with adaptive immune cells. However, the specific phenotype and function of helper ILC subsets in cardiovascular diseases are still poorly understood. In this review, we firstly highlight the distribution of helper ILCs in cardiovascular system and further discuss the potential contribution of helper ILCs in inflammation‐associated cardiovascular disease.

中文翻译：

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先天淋巴细胞在炎症相关心血管疾病中的朋友或敌人

作为一个独特的白细胞群体，先天淋巴细胞 (ILC) 参与免疫介导的疾病，并在损伤后的组织重塑中发挥关键作用。ILC 谱系可分为辅助 ILC 和细胞毒性 ILC。大多数辅助ILCs整合到组织结构中，产生不同类型的细胞因子，参与多种心血管疾病的发病机制，并与适应性免疫细胞形成错综复杂的反应回路。然而，辅助性 ILC 亚群在心血管疾病中的特定表型和功能仍然知之甚少。在这篇综述中，我们首先强调了辅助 ILC 在心血管系统中的分布，并进一步讨论了辅助 ILC 在炎症相关心血管疾病中的潜在贡献。