We aimed to assess the impact of POLG disease on mental health and quality of life in 15 patients using the Symptom Checklist-90-R (SCL-90-R) and Short-Form 36 Health Survey (RAND-36). We found increased scores in all nine subscales of SCL-90-R, particularly phobic anxiety, depression and somatization. Further, patients reported considerably lower scores in all RAND-36 domains. This study revealed a global decline in mental health and poor quality of life in patients with POLG disease and highlights the need for increased awareness and systematic assessment in order to improve their quality of life and mental health.

中文翻译：

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线粒体POLG疾病的心理健康和健康相关的生活质量

我们旨在使用 Symptom Checklist-90-R (SCL-90-R) 和 Short-Form 36 Health Survey (RAND-36) 评估 POLG 疾病对 15 名患者的心理健康和生活质量的影响。我们发现 SCL-90-R 的所有九个分量表的得分都有所增加，尤其是恐惧性焦虑、抑郁和躯体化。此外，患者报告的所有 RAND-36 领域的得分都相当低。这项研究揭示了 POLG 病患者的心理健康状况和生活质量在全球范围内下降，并强调需要提高认识和系统评估，以改善他们的生活质量和心理健康状况。