Immune activation contributes to the pathophysiology of psychiatric disorders. Administration of a single dose of lipopolysaccharides (LPS) has been shown to induce depressive- and anxiety-like behaviors in rodents through activation of the kynurenine pathway, increasing levels of the N-methyl-d-aspartate (NMDA) receptor agonist quinolinic acid. Conversely, repeated administration of LPS produces increased levels of the NMDA receptor antagonist kynurenic acid. Here we show that repeated LPS administration increases sensitivity to D-amphetamine and produces cognitive deficits and anxiety-like behavior. Together, our behavioral data suggests that repeated LPS administration may be useful to study the contribution of inflammation to psychiatric disorders such as schizophrenia.

中文翻译：

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重复给予 LPS 会加剧苯丙胺诱导的运动反应并导致小鼠学习缺陷

免疫激活有助于精神疾病的病理生理学。已显示单剂量的脂多糖 (LPS) 给药可通过激活犬尿氨酸途径，增加 N-甲基-d-天冬氨酸 (NMDA) 受体激动剂喹啉酸的水平，从而诱导啮齿动物的抑郁和焦虑样行为。相反，重复给予 LPS 会增加 NMDA 受体拮抗剂犬尿酸的水平。在这里，我们表明重复 LPS 给药会增加对 D-苯丙胺的敏感性，并产生认知缺陷和焦虑样行为。总之，我们的行为数据表明，重复使用 LPS 可能有助于研究炎症对精神分裂症等精神疾病的影响。