Background

Insulin-like growth factor-I (IGF-1) is an anabolic hormone that stimulates cell growth and division. The effects of IGF-1 may be beneficial (muscle growth/repair) or detrimental (increased risk of several types of cancer and mortality) for health. Dietary protein and physical activity are thought to be factors that modulate IGF-1.

Objective

This study analysed the relationships dietary protein vs IGF-1 and physical activity vs IGF-1 independently with a large sample size, and determined if/how physical activity affected the association between dietary protein and IGF-1 in healthy adults.

Methods

Regression models were used to assess the association between dietary protein and/or physical activity on serum IGF-1 in a cross-sectional sample of 60,677 healthy adults that were enrolled in the UK Biobank project.

Results

Dietary protein was positively associated with IGF-1 (0.030 nmol/L;95%CI 0.027–0.033;p < 0.001). Individuals undertaking 10–50 excess MET h/week of physical activity had 0.129 nmol/L greater IGF-1 than participants completing less than 10 excess MET h/week (95%CI 0.028–0.230). The “high” category of physical activity (>50 excess MET h/week) was not correlated with IGF-1 (−0.055 nmol/L;95%CI -0.185-0.076). When dietary protein and physical activity were included in the same model, physical activity did not change the relationship between dietary protein and IGF-1, nor visa-versa.

Conclusions

The positive association between dietary protein and IGF-1 was not influenced by physical activity. The former association was stronger than the latter. Thus, when seeking to adjust IGF-1 for possible health concerns, regulating dietary protein may be more pertinent than physical activity as a primary intervention.

中文翻译：

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体力活动、膳食蛋白质和胰岛素样生长因子 1：利用英国生物银行的横断面分析

背景

胰岛素样生长因子-I (IGF-1) 是一种合成代谢激素，可刺激细胞生长和分裂。IGF-1 的作用可能对健康有益（肌肉生长/修复）或有害（增加几种癌症和死亡率的风险）。膳食蛋白质和体力活动被认为是调节 IGF-1 的因素。

客观的

本研究以大样本独立分析了膳食蛋白质与 IGF-1 以及体力活动与 IGF-1 的关系，并确定了体力活动是否/如何影响健康成人中膳食蛋白质与 IGF-1 之间的关联。

方法

在 60,677 名参加英国生物银行项目的健康成年人的横断面样本中，回归模型用于评估饮食蛋白质和/或身体活动与血清 IGF-1 之间的关联。

结果

膳食蛋白质与 IGF-1 呈正相关（0.030 nmol/L；95% CI 0.027–0.033；p  < 0.001）。每周进行 10-50 次过量 MET 小时体力活动的个体比完成少于 10 次过量 MET 小时/周的参与者的 IGF-1 高 0.129 nmol/L（95% CI 0.028-0.230）。“高”类别的体力活动（> 50 过量 MET h/周）与 IGF-1（-0.055 nmol/L；95%CI -0.185-0.076）无关。当膳食蛋白质和体力活动被纳入同一模型时，体力活动不会改变膳食蛋白质和 IGF-1 之间的关系，反之亦然。

结论

膳食蛋白质和 IGF-1 之间的正相关不受体力活动的影响。前者的关联性强于后者。因此，当寻求针对可能的健康问题调整 IGF-1 时，调节膳食蛋白质可能比将体育活动作为主要干预措施更相关。