Precisely striking the bacterially infected site and avoiding damage to healthy tissues is vital for bacterial infection therapy. Herein, an intelligent antibacterial platform that triggers the aggregation of gold nanoparticles (AuNPs) on bacterial surface based on the acidic environment of bacterial infection was developed. Also, the AuNPs functionalized with an acidity-triggered moiety (Pep-DA) exhibited a charge-convertible properties to target bacterial infection sites. The positive charged acidity-triggered AuNPs endows the AuNPs aggregate on negatively charged bacterial surface in the infected site rather than in healthy tissues, achieving the threshold to interparticle plasmonic coupling effect among AuNPs, and killing bacteria accurately under NIR irradiation light. This acidity-triggered aggregation strategy provides an excellent therapeutic mode for treating focal bacterial tnfection with no critical damage to healthy tissues.

精确打击细菌感染部位并避免损害健康组织对于细菌感染治疗至关重要。在此，开发了一种基于细菌感染的酸性环境触发金纳米颗粒（AuNPs）在细菌表面聚集的智能抗菌平台。同样，用酸触发部分（Pep-DA）功能化的AuNPs表现出电荷可转化的特性，可靶向细菌感染部位。带正电的酸触发的AuNPs使AuNPs聚集在受感染部位而不是健康组织中带负电荷的细菌表面上，达到AuNPs之间颗粒间等离子体耦合效应的阈值，并在NIR照射光下准确杀死细菌。